what does off label means?
can i go shopee n buy and eat
DG Hisham: KKM MAY start using Ivermectin
DG Hisham: KKM MAY start using Ivermectin
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Jul 11 2021, 08:47 PM
Show posts by this member only | IPv6 | Post
#101
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Senior Member
7,126 posts Joined: Jan 2003 From: in ur base killin your d00dz |
what does off label means?
can i go shopee n buy and eat |
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Jul 11 2021, 09:16 PM
Show posts by this member only | IPv6 | Post
#102
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Senior Member
3,165 posts Joined: Feb 2015 |
QUOTE(JohnL77 @ Jul 11 2021, 07:27 PM) Big part of it is because a lot of the vulnerable people who would have died from covid already died from covid. US antibody testing based on commercial laboratory testing shows that about 22% of their population already infected. https://covid.cdc.gov/covid-data-tracker/#national-lab If it's based on blood donor antibody testing, about 33% already infected. https://covid.cdc.gov/covid-data-tracker/#n...-seroprevalence US and UK have about the same covid deaths per capita (almost 1,900 covid deaths per million people) so I think it's safe to assume that the percentage of UK population already infected with covid is about the same as the USA. In the USA only about 50% have been fully vaccinated. If plus the 22% to 33% already infected people, then up to 80% of their population already have immunity. If we assume half of the already infected people also took the vaccines, then at least 60% to 75% of their population already have immunity. QUOTE(JohnL77 @ Jul 11 2021, 08:45 PM) PCR vs antibody tests. Oh.. I didn’t grasp what you were trying to say.... so actually what you said was basically in line with what I said which was AZ vaccination was very effective in bringing down death rate or in your case you are saying vaccination and natural immunity acquired were responsible in bringing down the death rate...https://www.merriam-webster.com/dictionary/seroprevalence https://en.wikipedia.org/wiki/Seroprevalence So, both our observations correctly pointed out that the supposed ARR of AZ of 1.3% does not make sense |
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Jul 11 2021, 09:21 PM
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Junior Member
148 posts Joined: Oct 2009 From: Klang, Selangor D.E Status: Work Everyday |
Testing 1 2 12, mic check,.halo!!!!
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Jul 11 2021, 11:52 PM
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Junior Member
345 posts Joined: Jan 2021 |
QUOTE(cranx @ Jul 11 2021, 03:57 PM) Hospitals can no longer cope with the patients, doctors forced to play God? is this ready available in our hospital?This piece of news is great as it is no longer a CRIME for doctors to administer this drug. Just make sure to give credit where it is due when patients successfully recovered from the treatment. human consumption one. |
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Jul 12 2021, 12:06 AM
Show posts by this member only | IPv6 | Post
#105
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Junior Member
863 posts Joined: Apr 2019 |
QUOTE(aspartame @ Jul 11 2021, 10:55 AM) If AZ ARR is just 1.3%... how do you explain drastic drop in number of deaths in UK despite surging cases? The only explanation is that the vaccine AZ works...right? I think you are not getting the idea of ARR. ARR is dependent on the background risk of catching covid in the first place. For the lancet article, they had low ARR because during the time they were doing the trials the prevalence of Covid was not as high as during the second wave. you mention 5mil/60 mil population in the UK already infected with Sars2-covid. that is for the entire period since pandemic started in Mar 2020. ARR is always calculated base on a defined period (for eg the vaccine trial period). If you can imagine that over a period of X years, you will have 100% chance of catching covid, then the vaccine ARR = RRR. This is also why using ARR is problematic during an ongoing infectious pandemic cycle. ARR would be more appropriate if used during a steady state endemic level situation where the background risk is stable and constant. However during a pandemic, the force of the infection is dynamic, if its not well controlled by vaccines, SOP etc, the background risk would increase exponentially. The ironic thing is, the higher the background risk, the higher the ARR figures would be. This post has been edited by diffyhelman2: Jul 12 2021, 12:08 AM |
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Jul 12 2021, 12:23 AM
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Senior Member
6,914 posts Joined: Apr 2007 |
QUOTE(diffyhelman2 @ Jul 12 2021, 12:06 AM) I think you are not getting the idea of ARR. ARR is dependent on the background risk of catching covid in the first place. For the lancet article, they had low ARR because during the time they were doing the trials the prevalence of Covid was not as high as during the second wave. you mention 5mil/60 mil population in the UK already infected with Sars2-covid. that is for the entire period since pandemic started in Mar 2020. ARR is always calculated base on a defined period (for eg the vaccine trial period). exactly. If you can imagine that over a period of X years, you will have 100% chance of catching covid, then the vaccine ARR = RRR. This is also why using ARR is problematic during an ongoing infectious pandemic cycle. ARR would be more appropriate if used during a steady state endemic level situation where the background risk is stable and constant. However during a pandemic, the force of the infection is dynamic, if its not well controlled by vaccines, SOP etc, the background risk would increase exponentially. The ironic thing is, the higher the background risk, the higher the ARR figures would be. event rate multiply by time would be the real picture. |
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Jul 12 2021, 12:23 AM
Show posts by this member only | IPv6 | Post
#107
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Junior Member
172 posts Joined: Mar 2010 |
Messenger oh messenger
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Jul 12 2021, 07:30 AM
Show posts by this member only | IPv6 | Post
#108
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Senior Member
3,165 posts Joined: Feb 2015 |
QUOTE(diffyhelman2 @ Jul 12 2021, 12:06 AM) I think you are not getting the idea of ARR. ARR is dependent on the background risk of catching covid in the first place. For the lancet article, they had low ARR because during the time they were doing the trials the prevalence of Covid was not as high as during the second wave. you mention 5mil/60 mil population in the UK already infected with Sars2-covid. that is for the entire period since pandemic started in Mar 2020. ARR is always calculated base on a defined period (for eg the vaccine trial period). Oh.. thanks for detailed explanation .. I got a better idea of it now but all these medical things and statistics are confusing ...so, what is the article trying to say? Why did they bring up ARR then if ARR is only “accurate” during a steady state? So in a pandemic state, the stated RRR of higher figures like 90+% in Pfizer etc was accurate what... arggh ...anyway, my layman interpretation/observation was that vaccines were obviously very effective in UK now in bringing down death rateIf you can imagine that over a period of X years, you will have 100% chance of catching covid, then the vaccine ARR = RRR. This is also why using ARR is problematic during an ongoing infectious pandemic cycle. ARR would be more appropriate if used during a steady state endemic level situation where the background risk is stable and constant. However during a pandemic, the force of the infection is dynamic, if its not well controlled by vaccines, SOP etc, the background risk would increase exponentially. The ironic thing is, the higher the background risk, the higher the ARR figures would be. On another note... if ARR is low, are you saying once this pandemic die down , we might not need vaccination anymore as the low ARR means there is not much added benefit? |
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Jul 12 2021, 09:06 AM
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Senior Member
1,360 posts Joined: Mar 2010 |
QUOTE(6942nole @ Jul 11 2021, 11:52 PM) Yes available. And it seems KPJ Ampang Puteri already start administering Ivermectin for awhile without waiting for corrupt messenger's approval.https://forum.lowyat.net/index.php?showtopi...ost&p=101411512 |
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Jul 12 2021, 09:19 AM
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Junior Member
108 posts Joined: Sep 2020 |
mean on your own risk...
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Jul 12 2021, 09:24 AM
Show posts by this member only | IPv6 | Post
#111
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Senior Member
1,198 posts Joined: Aug 2009 |
QUOTE(cranx @ Jul 12 2021, 09:06 AM) Yes available. And it seems KPJ Ampang Puteri already start administering Ivermectin for awhile without waiting for corrupt messenger's approval. KKM denies the claim again. https://forum.lowyat.net/index.php?showtopi...ost&p=101411512 https://twitter.com/KKMPutrajaya/status/1413722079149522944 https://www.thestar.com.my/news/true-or-not...-treat-covid-19 QUOTE Health Ministry denies allowing use of Ivermectin to treat Covid-19 PETALING JAYA: The Health Ministry has denied a viral message claiming that they are allowing off-label usage of the anti-parasitic drug Ivermectin to treat Covid-19. "The off-label use of Ivermectin to treat Covid-19 is only for clinical trials – not on the request of patients in hospital," it said in a Facebook post on Saturday (July 10). cranx liked this post
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Jul 12 2021, 09:39 AM
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Senior Member
1,360 posts Joined: Mar 2010 |
QUOTE(edmund_yung @ Jul 12 2021, 09:24 AM) KKM denies the claim again. So doctors can continue to play God denying life saving medication to dying patients. Brilliant.https://twitter.com/KKMPutrajaya/status/1413722079149522944 https://www.thestar.com.my/news/true-or-not...-treat-covid-19 edmund_yung liked this post
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Jul 12 2021, 06:15 PM
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Junior Member
345 posts Joined: Jan 2021 |
QUOTE(cranx @ Jul 12 2021, 09:06 AM) Yes available. And it seems KPJ Ampang Puteri already start administering Ivermectin for awhile without waiting for corrupt messenger's approval. thanks!https://forum.lowyat.net/index.php?showtopi...ost&p=101411512 i armed myself some. these on power ppl tak boleh harap one. |
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Jul 12 2021, 07:20 PM
Show posts by this member only | IPv6 | Post
#114
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Senior Member
877 posts Joined: May 2006 From: Kuching |
If proven, kkm gotta eat humbe pie..
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Aug 3 2021, 01:18 AM
Show posts by this member only | IPv6 | Post
#115
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Senior Member
3,848 posts Joined: Dec 2009 From: Ampang |
Kuala Lumpur: Kementerian Kesihatan Malaysia (KKM) akan menjalankan ujian klinikal ke atas 500 pesakit untuk menilai keberkesanan penggunaan Ivermectin. Ketua Pengarah Kesihatan Tan Sri Dr Noor Hisham Abdullah berkata, objektif utamanya adalah untuk melihat sama ada ubat terbabit dapat merawat secara efektif pesakit yang berada pada tahap awal Covid-19 dan mencegah daripada beralih ke kategori empat atau lima. "Kita juga akan melihat perbezaan dari segi jumlah kematian, pengudaraan mekanikal, jumlah berapa pesakit yang dirawat di Unit Rawatan Rapi (ICU) dan kesan di sebalik penggunaannya. "Satu kumpulan akan menerima Ivermectin oral dengan dos 0.4 miligram (mg)/kilogram) (berdasarkan berat badan) setiap hari selama lima hari berturut-turut sementara kumpulan yang lain hanya akan mendapat rawatan biasa tanpa ubat terbabit," katanya kepada Harian Metro. Dr Noor Hisham berkata, setakat ini 200 pesakit sudah sudah menjalani ujian klinikal terbabit dan menjangkakan 500 pesakit akan dicapai sehingga September ini. "Adalah penting untuk tahu bahawa dos Ivermectin yang digunakan dalam ujian klinikal ini lebih tinggi dari dos dibenarkan untuk jangkitan parasit. "Subjek kajian dipantau rapi oleh doktor berpengalaman sekiranya berlaku apa-apa dalam tempoh kajian klinikal terbabit," katanya. Beliau berkata, kajian itu didaftarkan di clinicaltrials.gov dan pada sesiapa yang berminat boleh melihat dengan jelas mengenai protokol kajian bagi memastikan kajian telus dan untuk elakkan sebarang prejudis pada masa akan datang. "Keberkesanan ubat ini di dalam proses rawatan Covid-19 mesti berdasarkan bukti saintifik dan bukan pandangan peribadi dan sentimen orang awam," katanya. Selain daripada doktor dari jabatan penyakit berjangkit, seramai 140 orang terbabit dalam ujian klinikal ini terdiri daripada pakar perubatan, pegawai perubatan, ahli farmasi dan pegawai penyelidikan dari Pusat Kajian Klinikal (CRC) dari 18 hospital kerajaan. |
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Aug 3 2021, 08:39 AM
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Junior Member
55 posts Joined: Apr 2013 From: Londo Bell |
Finally decided to give off label use... If not got shouted in parliament, menteri air suam probably still sleeping on the job again
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Aug 3 2021, 08:42 AM
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Senior Member
1,709 posts Joined: Jan 2003 From: Kedah Khap Khoun Khap (4K) |
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