The recommended dosage is 12-16mg daily depending on your body weight but this is the standard for most normal weight adults. 200ug/kg bw/day.

When they used Ivermectin together with other drugs (epidemiological studies, cohort studies etc), these were slammed by critics as confounding factors. Hence to them the only evidence acceptable is dbRCT using Ivermectin as the sole source of intervention vs placebo (not standard of care as this is another source of confounding).

This post has been edited by diffyhelman2: Jul 11 2021, 08:18 AM

I was in US for ten years. Every winter the mass media and radio will mass advertise for “people to get their flu shots”. Mostly targeting the elderly. I never once took it. Every year only 50-60% take the flu shot. And US is one of the highest usage of flu vaccination shots in the world.

Here in Malaysia i dont think even 10% of the population ever take flu shot. Now suddenly govt is normalizing the idea of everyone must vaccinate or we can’t open up.

I think you are not getting the idea of ARR. ARR is dependent on the background risk of catching covid in the first place. For the lancet article, they had low ARR because during the time they were doing the trials the prevalence of Covid was not as high as during the second wave. you mention 5mil/60 mil population in the UK already infected with Sars2-covid. that is for the entire period since pandemic started in Mar 2020. ARR is always calculated base on a defined period (for eg the vaccine trial period).

If you can imagine that over a period of X years, you will have 100% chance of catching covid, then the vaccine ARR = RRR.

This is also why using ARR is problematic during an ongoing infectious pandemic cycle. ARR would be more appropriate if used during a steady state endemic level situation where the background risk is stable and constant. However during a pandemic, the force of the infection is dynamic, if its not well controlled by vaccines, SOP etc, the background risk would increase exponentially. The ironic thing is, the higher the background risk, the higher the ARR figures would be.

This post has been edited by diffyhelman2: Jul 12 2021, 12:08 AM