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 Get Cheaper Hepatitis C Treatment In Malaysia, Generic Harvoni With High Cure Rate

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TSdtdw
post Jan 15 2016, 03:40 PM, updated 7y ago

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user posted image

www.msf.org/article/access-patent-challenge-hearing-gilead-hepatitis-c-drug-sofosbuvir-starts-india

Patent.

"Patents for sofosbuvir have been rejected in Egypt, China and Ukraine, and further patent oppositions have been filed in Argentina, Brazil, Russia, Thailand and the EU."

I think Malaysia granted patent to Sofobusvir.

Another point I wanted to highlight:

“Gilead wants the world to think their licensing deals have solved the global problem of access to this medicine, but today countries like Thailand, Malaysia and Brazil are being asked to pay thousands of dollars for sofosbuvir from Gilead, when Indian generic versions of the drug are now available for as little as $335 per 12-week treatment,”

===

The original post where I started writing (which I might change in the future):

Do you have Hepatitis C but have been told that it cost a bomb (84k USD), and that past treatment were with very low success rate plus unfavorable side effects?

Then you need to know that now, you can indeed cure this disease with higher success rate, and it cost less than RM 10k (even I got it for as low as RM 5.4k).

I will update this with more info as I progress and add missing bits when necessary.

The reason why I write this is because there is very little information about this topic when it comes to our country, so I want to spread the information.

Important!

Before you go out and buy the meds, read this first.

Please do not import this or any medication without a doctors' prescription letter. And you need to see a specialist before deciding to go ahead and purchase this, or any other medication. Depending on your genotype, different combination of the generic meds is needed, and they vary in price.

Another point is that our country's personal drug import law set by MOH says 1 person can only bring in 1 month's supply of personal use medication/supplement. If any of the sources tell you they don't need a prescription letter, there's a very high chance the product will be held at kastam, and/or the relevant authorities will give you a warning letter, which I read somewhere you can either be fined, or jailed.

If, however, the doctor you are visiting doesn't know about this new medication and tell you to not believe it, then the doc should be viewed as incompetent if he is truly a specialist. My advice is to change to another doc. The name of the doc that knew and recommended this treatment to my dad is this :

https://www.ramsaysimedarby.com/doctor_deta...al-kanagasabai/ (link updated)

If you cant get accessed to this doc however, here's the method to get the medication and test:

1. Ask your doctor to issue a prescription letter to import in the generics (You need to do blood test first to determine genotype and viral load count, then visit fixhepc.com to check for the generics)
2. Do a periodic blood test to determine viral load count and liver health

Background
My dad is living with Hep C for the past 10 years, and have developed cirrhosis with quite a significant liver damage. We didn't know he had a pretty big liver scarring until he had a big tummy in less than a month. The doc told him it was water retention due to too much sodium in the body, which the liver can't filter and pass.

Our family knew he had Hep C, but as usual, we didn't investigate any further, because he didn't develop any symptom except for tummy bloating. Then the doc told us, there is a new generic that we can import in, that can cure hep c.

Current Situation
Right after the doc told us there's a cure, it's cheaper, and have high success rate, I went to google to search for this so called miracle cure. Firstly, some info about the pill. The patent name is Harvoni, and is patented by Gilead. Harvoni consist of Ledipasvir/sofosbuvir. So why do we need to go through so much trouble to get this? Click read more below in the spoiler.

Read more

» Click to show Spoiler - click again to hide... «


Personal Update

» Click to show Spoiler - click again to hide... «


Buying process - Sources

This is a concern many people have, including me. The 4 main countries where you can get the generic from is India, China, Bangladesh, Australia.

They vary in price and trustworthiness. You can either fly there and bring back the meds, or import it. Many people have flown to these countries to get it themselves. I chose to import it although both options have their own risk. For the record as stated, I've had no trouble with Incepta Pharmateucals

India
One of the country licensed by Gilead to produce and sell the generic pill. Many companies and 3rd party are selling it. They range from so expensive, to so cheap (compared to other licensed generic manufacurer) you will need to think twice. So the main issue here is whether you can find a trusted source to buy from. The first person that went public about buying it from India is Greg Jefferys. If you are interested to get it from India, my suggestion is to go through him, his email can be found in his blog.

The price he quoted me is more expensive than I would buy from Incepta directly(see below), and he didn't want to recognize the cheaper price I told him about, saying it might be a scam. That's the price to pay for a middle man to do the job, IMO though, you really don't need to go through him and just get it from Incepta. Also another point is, I have posted on fixhepc and the community there including Dr James himself is all negative on the cheaper side of things, but they also don't want to take the effort to do further research on cheaper alternatives.

Bottom line: Only use this option if you're so hard pressed on budget, but you risk your life at the same time.

China
I am not familiar with getting it from China, but fixhepc has given ways to obtain it there. They sell it in powder form, and you would need to get a company that can compound it to the correct dosage. Some people had even managed to DIY it. Fixhepc however, got it from Mesochem, compound it, and then sell it to you.

Bangladesh
There's currently 2 companies that are listed in fixhepc.com as trusted source. The first is Incepta Pharmaceutical, and their Sof+Led product label name is Twinvir. As stated earlier in my post, Twinvir was first to release it in finished form of Sof+Led combo. They get the API from China, compound it, and sell it in finished form. They sent the pills to Australia to be tested by their lab, managed by Dr James Freeman of fixhepc. It turned out to be exact copies of Harvoni. The 2nd company Beacon Pharma is selling a different combo, which is sof/dac, they are cheaper, but due to lesser data being reported than sof+led combo, you don't really see much info online. Sof+Dac is used to treat type 3.

Australia
This is in my opinion the best of the bunch. Firstly, as mentioned earlier it's straight out of fixhepc, and the chances of them being a scam, wrong, mistake, or whatever bad things you can think of is very slim. Secondly, fixhepc is mentioned in lots of big publications, and Greg and Dr James (founder of fixhepc) mentions each other. The current pricing they have quoted me is 1600 USD. There is one caveat which I am not very certain of, is that you can only get it via a redemption etrial as explained here http://fixhepc.com/redemption-3 which might mean there is a chance you might not be qualified. If anyone is willing to share the details with me, I'll be happy to add.


Genotype and it's treatment
This is one area which I have very little knowledge about. So far I've only talked about harvoni which is treating type 1a for my dad, and I haven't much covered the rest unless someone with other type decides to come forward and be the voice for the community. I only post and update what I can, as far as evidence and data is concerned. As you can see, different genotype needs different combination of the treatment. This article linked is about Genotype Specific Treatments http://fixhepc.com/getting-treated/genotyp...-treaments.html

For genotype 1 which is combination of Sofosbuvir + Ledipasvir OR Sofosbuvir + Daclatasvir +/- Ribavirin. The doc didn't recommend sof+dac with riba combo, and obviously I also don't know if it's right or wrong. All I know is fixhepc has said sof+led is generally OK. It is the 2nd most common genotype in Malaysia, with type 3 being the most according to
www.msgh.org.my/resources/managementhepatitisc.htm

For genotype 3 you need Sofosbuvir + Ribavirin OR Sofosbuvir + Daclatasvir +/- Ribavirin. I can only post information but I won't have any evidence nor data, since I have no reason to ship in this combo nor will my dad and I be able to provide any proof of success. If you're type 3 and the doc has suggested you this, please post it here so you can help others too.

This post has been edited by dtdw: Feb 16 2018, 03:48 PM
dewill
post Jan 15 2016, 03:46 PM

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Good to hear your dad found his medication. Is better if our malaysia's pharmacy got carry.
wut2du
post Jan 15 2016, 03:56 PM

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Great information sharing!!
TSdtdw
post Jan 16 2016, 10:23 AM

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Thanks !

To all reading:
Please spread the awareness by sharing this thread as far as you can, you'll never know who you might be of help.

This post has been edited by dtdw: Jan 3 2018, 10:57 AM
TSdtdw
post Jan 17 2016, 11:13 PM

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http://timesofindia.indiatimes.com/india/Desi-generics-firms-pave-way-for-cheaper-hepatitis-C-drug/articleshow/50609836.cms

The prices of the generics are falling. Please take these as a rough figure of where it's headed but don't expect the price to be so cheap just yet, as we don't have enough sources to prove that they are legit if bought at that price.

But what I wanted to highlight here is that, multiple sources have cited the generics cannot be imported to our country because we have granted patent to Gilead for Sofosbuvir. The problem still remain, that no one has gone public about whether they have successfully imported it to malaysia and able to pass kastam (even with doctors prescription letter).

The shipment from Bangladesh is now going through their kastam. I will update when it goes though our kastam as well.

Peace.

This post has been edited by dtdw: Apr 27 2017, 01:51 PM
TSdtdw
post Jan 19 2016, 02:35 PM

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Good news! Package from Bangladesh arrived safely via DHL. thumbup.gif

user posted image

The person name Alimul Razi has been very responsive via email and whatsapp. If you need, he can be found frequently in a few forums. I got his contact from fixhepc.com. Since this is quite a sensitive subject, I'll most likely link it to fixhepc so that you can make informed decision from that forum rather than from here, which is mainly to raise awareness and cover some current news around hep c cure.

More Pictures:
» Click to show Spoiler - click again to hide... «

TSdtdw
post Jan 22 2016, 11:01 AM

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Today is a good day. If you count yesterday too, it's also good.

My dad started the treatment yesterday, with a green light from the doc.

Today, I've received a PM from a reader about a family member diagnosed with hep c and was also finding for information online. Don't worry, I will not disclose anything anyone wishes to send me whether it is questions or news. I am not a professional in any medical field, and probably not as up to date as Greg, but If there's anything I can help in my limited capacity, I will.

At first, I received 2 helpful replies, which I am thankful for. But after a while, I kept doubting if there's any use in creating a sub thread in a forum that is not geared specifically towards certain medical condition that other people can chip in.
As you all know, we only have one forum, unlike in the US/UK/AUS where they have tons of forums to seek advice and find for more information.

Now that someone PMed me, I am reassured that in time, I can reach to more people.

I will update the process on the OP regarding purchase process and trusted sources. We all know it's easy to get scammed, and must be prepared not to get scammed. Stay tuned.
TSdtdw
post Feb 17 2016, 11:31 AM

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Nothing much has been happening, a test is done to evaluate his condition, and it is OK. Not getting worse, but also not a viral load test which is more important, which is coming up soon.

Updated the post with information of the doc treating my dad which is long overdue. Only caught my attention today when someone PMed me about it because the person's doc did not recognize this new meds (which is not really new if the doc stays up to date on his own research. It's only new on the cheaper side of things due to the ability to buy it generically).

Glad that I could help in some way.
Ramjade
post Feb 17 2016, 01:29 PM

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You should also start your father on milk thistle + dandelion. In addition to that, take turmeric with Virgin coconut oil + fresh crush black pepper.
TSdtdw
post Feb 17 2016, 06:26 PM

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Thanks for the advice. Many of these are supplements which i think should be taken after he finishes the course of medication. He has taken lots of supplements that cost far more than what was paid for these if you add the long term usage to it.

For example there's this L PRO thing, and someone also recommended Essentiale Forte to him, which I immediately researched and said no.

The reason is because this is a hep c virus. A virus that must be erradicated first. Supps preserve, but they don't cure. The doc also said the same thing which I agree : "you gotta kill the virus first, which is the root of the problem, then you can do whatever you want after that"

So I would be very careful on advicing supps which has a high chance of a placebo.

This post has been edited by dtdw: Feb 17 2016, 06:28 PM
Ramjade
post Feb 17 2016, 08:39 PM

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QUOTE(dtdw @ Feb 17 2016, 06:26 PM)
Thanks for the advice. Many of these are supplements which i think should be taken after he finishes the course of medication. He has taken lots of supplements that cost far more than what was paid for these if you add the long term usage to it.

For example there's this L PRO thing, and someone also recommended Essentiale Forte to him, which I immediately researched and said no.

The reason is because this is a hep c virus. A virus that must be erradicated first. Supps preserve, but they don't cure. The doc also said the same thing which I agree : "you gotta kill the virus first, which is the root of the problem, then you can do whatever you want after that"

So I would be very careful on advicing supps which has a high chance of a placebo.
*
Well I think one should take together as milk thistle and dandelion protects the liver. So you kill the virus and at the same time help to repair the liver. You can always get the seeds yourself if you are scared if it's placebo., grind it up and drink it.

Turmeric is not a placebo. You don't need a supplement for turmeric and is cheap.

Look into need leaves also. A very potent antiviral plant. Neem can be found easily in front of Indian temples, Indian houses. neem is the most bitter stuff I have ever tasted.

This post has been edited by Ramjade: Feb 17 2016, 08:44 PM
TSdtdw
post Feb 18 2016, 08:17 PM

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QUOTE(Ramjade @ Feb 17 2016, 08:39 PM)
Well I think one should take together as milk thistle and dandelion protects the liver. So you kill the virus and at the same time help to repair the liver. You can always get the seeds yourself if you are scared if it's placebo., grind it up and drink it.

Turmeric is not a placebo. You don't need a supplement for turmeric and is cheap.

Look into need leaves also. A very potent antiviral plant. Neem can be found easily in front of Indian temples, Indian houses. neem is the most bitter stuff I have ever tasted.
*
You are very helpful. I only fear that adding other things will skew the result, whether it's possitive or negative. What's important when doing such test is having absolute data. But of course that's not entirely possible, since some of the things we take daily affects the outcome even if it's not a supplement, plus many other factors.

If they (the supps) all relate very closely to the liver condition however, that data will be skewed and we wouldn't have known for certain what helped, or what didn't help. Although honestly speaking, I also want him to speed up the recovery. All these things I have read before it's very good, but for the sake of clinical test with higher accuracy, we have decided to not take it. smile.gif
Ramjade
post Feb 18 2016, 09:01 PM

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QUOTE(dtdw @ Feb 18 2016, 08:17 PM)
You are very helpful. I only fear that adding other things will skew the result, whether it's possitive or negative. What's important when doing such test is having absolute data. But of course that's not entirely possible, since some of the things we take daily affects the outcome even if it's not a supplement, plus many other factors.

If they (the supps) all relate very closely to the liver condition however, that data will be skewed and we wouldn't have known for certain what helped, or what didn't help. Although honestly speaking, I also want him to speed up the recovery. All these things I have read before it's very good, but for the sake of clinical test with higher accuracy, we have decided to not take it.  smile.gif
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If it's my father, I will do everything to speed up his healing. What's there higher accuracy for? Unless the drug companies pay you for clinical trial, then it's right now taking extra stuff. But if they didn't pay you, why bother about accuracy? The goal here is get better faster. If you want to fully depend on drugs, you can wait a long time as drug companies are more interested in getting their money back.

You can go search up at ncbi.nlm.nih.gov about research using turmeric on liver. Yes, they are still in research but they will never be mainstream as you can't make money selling turmeric tea. You have to extract the natural substance, modify it and sell it as something. Btw, better to go for whole turmeric rather than just curcumin.
TSdtdw
post Feb 18 2016, 09:25 PM

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I probably wont go into more details on my decsision but you have to understand that when you're on a course of treatment you are monitored by the doc. And when you have a specific virus to kill using drugs, you need to have proof that the drug is responsible for it.

Lets say the test shows his viral load count is lower. How do you proof it? And if it went up some more, what causes it? Treating liver condition is a long process, I believe for any other long term sickness is the same thing. The viral load test has to be done 4 weeks after, and then 12 weeks after. And then years later.

If the meds worked, good, that means he doesnt even need supplement. If he took the supps with the med, and the test result showed improvement, is it all hooray? Not at all, because the virus might come back, but he will be hapily thinking the supps were helpful, whereas there's a 24 weeks course that could have completely kill the virus due to his cirosis.

Now if someone wants to take the risk and use supps to try and kill the virus, they can. I don't recommend it, but is that person willing to risk it? Do he have stash of money lying around to proof that it works? If so, that person will contribute alot to the community. Perhaps you can contribute too if you have a certain condition.

Hence why its all about data. If you go fixhepc site, its all data everywhere. I rather believe in data, cure it with data, then consider other things.
Ramjade
post Feb 19 2016, 07:33 AM

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Bro,

Who mentioned anything about stopping drugs? What I am saying is combine both. Like I said repair should be done at the same time as killing the virus. One thing medical world is they will never acknowledge stuff like milk thistle, turmeric for hepatoprotection.

Btw data from ncbi.nlm.nih.gov are raw data and not just hearsay. Is not any blog. Those are research papers, journals done by researchers.
TSdtdw
post Feb 19 2016, 10:42 AM

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Haha bro, you need to read again, I didn't mention any word of stopping it anywhere. I don't wanna turn this into our own argument, but you need to go read all the things related to hep c again.

I will say this, unless you're in the same situation as me, you can express your thoughts freely without implication. But to a condition sufferer, it's a whole different story. So, unless you are directly related to the condition we are discussing here, which is a virus attacking the liver, then I'd very much appreciate that you refrain from confusing the patients, and family members related to the patient.

Like I said, if someone here that's a first party with hep c willing to take the supplements being recommended by you or anyone, and then take a before and after viral load test to show results, they can. And unless they do it, and are convinced enough to do it to proof to other patients that it works, then we shouldn't say and recommend these other sources to any patients.

You have good intention I appreciate that, but this is a sensitive topic we have to tread carefully. As a 3rd party to other illness, I also can recommend all these supps. I myself is facing a certain IBS, which many ppl would have said IBS isn't a real thing and it's all in the mind. Do this, take this, sure. I'm on course of alot of IBS related supps, no doc recommendation at all. But this illness doesn't lead me to a certain health threat like death, which is what this virus can do to a patient.

One more thing, as you know older people tend to believe almost everything written on the internet. Do you know how my dad got into such a bad condition? Because he read that certain salt from certain place helps his body to be more healthy. Little did we know that taking too much salt leads to sodium and ultimately causing water retention. Lucky? I don't know. If he didn't show external symptom, we all wouldn't have known how bad his liver condition is. But there were alot worse stuffs that the chinese 'doctors' recommend him to take, which he took without much use, all without solid evidence or data.

What is proven with lots of data though, is harvoni, and there isn't anywhere mentioning the patients needing to take any other things to help the recovery.

This post has been edited by dtdw: Feb 19 2016, 10:53 AM
Ramjade
post Feb 19 2016, 11:19 AM

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What's there to confuse the patient? You are taking the drug along with proven liver protective herbs. Turmeric black pepper and coconut oil are easily available. You don't need to spend a fortune for those. Less than rm100 enough to last for at least 1-2 months.
I back my statements with facts.
QUOTE
Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

http://www.ncbi.nlm.nih.gov/pubmed/23903236

QUOTE
This study showed that turmeric extract repressed the production and secretion of hepatitis B surface antigen from HepG 2.2.15 cells, an activity that is mediated through the enhancement of cellular accumulation of p53 protein by transactivating the transcription of the p53 gene as well as increasing the stability of p53 protein

http://www.ncbi.nlm.nih.gov/books/NBK92752/
Hepatitis B virus might not be same with the C virus but they are in the same family.

QUOTE
The purpose of the study is to investigate the hepatoprotective effect of fermented turmeric powder (FTP) on liver function in subjects with elevated alanine transaminase (ALT) levels.

Of the 48 subjects, 26 randomly received FTP capsules and 22 received placebo. The FTP group showed a significant reduction in ALT levels after 12 weeks of treatment compared with the placebo group (p = 0.019)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600681/

QUOTE
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

http://www.ncbi.nlm.nih.gov/pubmed/20026048

Did your father have cirrhosis? Did the doctor tell you that you must restrict oil in his diet? Did he also mentioned that MCT oils are recommended for cirrhosis patients? Coconut oil is the only oil with > 50% MCT. Best part is Virgin coconut oil is also anti-viral. Of course must restrict also.

Also did he give your father vitamin K supplementation?

Curcumin is just one part of turmeric. Better to take the whole root for maximum effectiveness.

This post has been edited by Ramjade: Feb 19 2016, 11:34 AM
TSdtdw
post Feb 20 2016, 10:28 AM

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None of us know anything for sure. I don't know how this or any other supps will work.

Here's what is said by this article. http://www.webmd.com/hepatitis/features/hepatitis-c-alternative-treatments - "Dietary and herbal supplements can't cure hepatitis C, but many people take them to try to ease their symptoms or get relief from the side effects of treatment. Do they work? For most of these products, scientists don’t have a firm answer."

Now I'm not saying people can't take it. Everyone is free to express their opinion, and patients have their own choice. If I wanted to restrict public opinion I would've created a blog and publish all the info there, but I chose to do it in the forum. I do applologize if I am on the offense side of things in my recent comments.

Here's the thing to everyone: No matter what you take, and which path you choose, always confirm it with data. If you decide to take the supps instead of the more expensive pills, that doesn't mean you don't need to go for a checkup for viral load test. My dad took lots of supps, but he didn't go for a checkup and just assumed that he is OK. Here's just a sample of the supps he took:
» Click to show Spoiler - click again to hide... «

Some still haven't finish. We have decided to defer it until post-treatment with hopefully SVR12

What @ramjade suggested is to take the combination of pills and supplements. As I have mentioned it before, it [could] be a waste of money or effort. It's like saying, well why take 1 vitamin C when taking 5 vitamin C is better? Hence, why my comment is about choosing. Do you really need to take the pills and supps together? There's little to no evidence that taking drugs with the supps speed up the healing.

This post has been edited by dtdw: Apr 27 2017, 01:52 PM
Ramjade
post Feb 20 2016, 11:03 AM

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QUOTE(dtdw @ Feb 20 2016, 10:28 AM)
None of us know anything for sure. I don't know how this or any other supps will work.

Here's what is said by this article. http://www.webmd.com/hepatitis/features/he...tive-treatments - "Dietary and herbal supplements can't cure hepatitis C, but many people take them to try to ease their symptoms or get relief from the side effects of treatment. Do they work? For most of these products, scientists don’t have a firm answer."

Now I'm not saying people can't take it. Everyone is free to express their opinion, and patients have their own choice. If I wanted to restrict public opinion I would've created a blog and publish all the info there, but I chose to do it in the forum. I do applologize if I am on the offense side of things in my recent comments.

Here's the thing to everyone: No matter what you take, and which path you choose, always confirm it with data. If you decide to take the supps instead of the more expensive pills, that doesn't mean you don't need to go for a checkup for viral load test. My dad took lots of supps, but he didn't go for a checkup and just assumed that he is OK.

What @ramjade suggested is to take the combination of pills and supplements. As I have mentioned it before, it [could] be a waste of money or effort. It's like saying, well why take 1 vitamin C when taking 5 vitamin C is better? Hence, why my comment is about choosing. Do you really need to take the pills and supps together?  There's little to no evidence that taking drugs with the supps speed up the healing.
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Turmeric is cheap la. sweat.gif Virgin coconut oil is cheap as one bottle can last ~3 months. Easily available from aeon, aeon big, tesco.1kg of black peppercorn is also cheap.

There's little evidence that taking drugs with supplements speed up the healing? Turmeric was in the cross hair of pharmaceutical companies back in the 70s because they wish to patent turmeric as a wound healing agent. Thank god, it didn't happen. Btw, the mechanism of wound healing internally and externally are the same.
QUOTE
Curcumin has also been shown to have significant wound healing properties. It acts on various stages of the natural wound healing process to hasten healing.

http://www.ncbi.nlm.nih.gov/pubmed/25200875

Btw, did your doctor prescribe vitamin K for your father? Cirrhosis patients should receive vitamin K as the liver is unable to produce vitamin K.

This post has been edited by Ramjade: Feb 20 2016, 11:04 AM
kaikeri
post Mar 16 2016, 09:14 PM

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Thanks for sharing this. My brother suffered from this disease since late 90s because of blood transfusion. I'll check more on the twinvir.

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