AI Overview



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Metformin, a diabetes drug, shows promise as an anti-aging agent by activating cellular cleanup (autophagy), reducing inflammation, and improving metabolic health, potentially extending lifespan and "healthspan" (healthy years) in animals and reducing age-related disease risks in humans. While early studies and monkey research are encouraging, showing reduced brain aging and better cognition, large human trials like the TAME trial are still needed to confirm its anti-aging potential for everyone, as results are mixed and potential side effects exist, but its safety profile makes it a key drug for aging research.
How it works (Potential Mechanisms)
Activates Autophagy: Promotes cellular self-cleaning to remove damaged components.
AMPK Pathway: Activates AMP-activated protein kinase (AMPK), a key energy sensor, and inhibits mTOR, a growth pathway, slowing cell proliferation.
Reduces Inflammation: Fights chronic inflammation, a hallmark of aging.
Improves Metabolism: Helps regulate energy, potentially reducing risk for cardiovascular and neurodegenerative diseases.
Evidence and Research
Animal Studies: Extended lifespan in worms (C. elegans) and mice, and slowed brain aging in monkeys.
Human Studies (Observational): Showed reduced incidence of age-related diseases (like cancer, heart disease) and lower overall mortality in diabetics and even some non-diabetics.
Clinical Trials: The TAME trial (Targeting Aging with Metformin) is a major step to test if it can delay multiple age-related diseases in non-diabetics.
Considerations
Not Approved for Anti-Aging: It's currently for diabetes; use for anti-aging is off-label and experimental.
Mixed Results: Some studies show great promise, while others highlight weaknesses in early evidence, especially in non-diabetic populations.
Side Effects: Potential issues like reduced muscle mass or vitamin B12 deficiency can occur.
Conclusion
Metformin is a leading candidate for anti-aging, but more rigorous human trials are necessary to fully understand its benefits, risks, and effectiveness in healthy individuals.

Helps with prevention of dementia as well iirc
And Metformin cheap as chips
Rm1.50 for a blister of 10

Honestly, i kept it to myself for a few days, until i managed to turun kan the level.. then I told some of the famili member EHEHEHE