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 Pituitary tumor. Need MC with no surgery. Help!, Can I get MC if I don't want surgery?

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TSsyndi
post Oct 2 2014, 08:59 PM, updated 10y ago

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I was diagnosed with Putuitary Tumor as big as 3cm. The tumor is pressing on my optic chiasm and causing my visual blurring.

Can I still request my neurosurgeon to issue MC for me to rest at home for 1 month even if I don't want to perform surgery? My daily office work becomes burdening as my eyesight is no longer good. It is difficult for me to read documents / laptop.

Appreciate if anyone can advise me.

Thanks.

colt45
post Oct 2 2014, 09:03 PM

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hi..i was also diagnose with putuitary tumor in 2001..
when for the operation as my vision was becoming blurry and shrinking..
Better go for the operation..

How old r u?

Yes ur neurosergon can give u MC
SUSTham
post Oct 2 2014, 09:07 PM

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If your employer approves, you can request your doctor to write it.

The surgeon gave me about two weeks off after hemorrhoids surgery
over a decade ago, but when I had came down with complications and
a high fever as well after that, he gave me another two.

It was alright with my employer.


Why are you not going for surgery ? It is inevitable, and the tumor
will just keep growing.




SUSTham
post Oct 2 2014, 09:44 PM

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Seems to be very common.


'' Up to 20% of people have pituitary tumors. Many of these tumors do not
cause symptoms and are never diagnosed during the person's lifetime. ''

http://www.nlm.nih.gov/medlineplus/ency/article/000704.htm




Surgery looks relatively safe with the endoscope these days.


Endoscopic endonasal transsphenoidal surgery of 1,166 pituitary adenomas.

http://www.ncbi.nlm.nih.gov/m/pubmed/25270611



Endoscopic supraorbital eyebrow approach for the
surgical treatment of extraaxialand intraaxial tumors.

'' The endoscopic supraorbital eyebrow approach is a safe and effective
minimally invasive approach to remove extra- and intraaxial anterior skull base,
parasellar, and frontal lesions, promoting a rapid recovery and short hospital
stay. The location of the eyebrow incision demands a meticulous cosmetic
closure, but, with proper technique, cosmetic results are excellent. ''

http://www.ncbi.nlm.nih.gov/m/pubmed/25270140/





Have you checked out Cyberknife ? Beacon Hospital has a Cyberknife machine.


Hypofractionated stereotactic radiotherapy with CyberKnife for
nonfunctioning pituitary adenoma: high local control with low toxicity.

'' Hypofractionated SRT appears useful for protecting the visual nerve and
neuroendocrine function, especially for tumors located near the optic
pathways and large tumors. ''

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145469/



Nilai Cancer Institute has the Trilogy image-guided linear accelerator.
Enquire with them if they can use it in your case. Show them this study.


Initial clinical experience with frameless optically guided
stereotactic radiosurgery/radiotherapy in pediatric patients.

''Frameless stereotactic optically guided radiosurgery and radiotherapy
provides a feasible and accurate tool to treat a number of benign and
malignant tumors in children with minimal treatment-related morbidity. ''

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691523/




Ministry of Health's writeup on Trilogy.

http://www.moh.gov.my/index.php/database_s...ownload/347/104




Recent advances in pituitary tumor management.

http://www.ncbi.nlm.nih.gov/m/pubmed/21844711







This post has been edited by Tham: Oct 2 2014, 09:46 PM
ngaisteve1
post Oct 3 2014, 01:26 PM

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QUOTE(syndi @ Oct 2 2014, 09:59 PM)
I was diagnosed with Putuitary Tumor as big as 3cm. The tumor is pressing on my optic chiasm and causing my visual blurring.

Can I still request my neurosurgeon to issue MC for me to rest at home for 1 month even if I don't want to perform surgery? My daily office work becomes burdening as my eyesight is no longer good. It is difficult for me to read documents / laptop.

Appreciate if anyone can advise me.

Thanks.
*
I think you can request MC from doctor. What doctor's advice for that tumor?
TSsyndi
post Oct 3 2014, 04:42 PM

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QUOTE(colt45 @ Oct 2 2014, 09:03 PM)
hi..i was also diagnose with putuitary tumor in 2001..
when for the operation as my vision was becoming blurry and shrinking..
Better go for the operation..

How old r u?

Yes ur neurosergon can give u MC
*
I'm 32 yrs old. I'm now undergoing the kentogenic diet as recommended by my friend who did not operate removing tumor but heal after 1 month by starting the diet.

I did not have the chance to speak to my surgeon requesting MC as his assistant rejected my request immediately through phone call when she learnt that I refused to do surgery immediately.

I'm puzzled. Should the doctor respect my decision and issue MC according to my condition?
TSsyndi
post Oct 3 2014, 04:47 PM

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QUOTE(Tham @ Oct 2 2014, 09:07 PM)
If your employer approves, you can request your doctor to write it.

The surgeon gave me about two weeks off after hemorrhoids surgery
over a decade ago, but when I had came down with complications and
a high fever as well after that, he gave me another two.

It was alright with my employer.
Why are you not going for surgery ?  It is inevitable, and the tumor
will just keep growing.
*
As I believe in human natural healing capability and kentogenic diet (with lots of info reseach), I choose to give myself a chance to go for 3-4 months. It's been 2 months since I was diagnosed with the pituitary tumor and it has not grown as shown in my 2nd MRI results.

My employer has no objection on my long medical leave. They just request me to get MC from doctor. And, I don't understand why neurosurgeon's assistant refused to help me to get doctor's MC when I request so.
TSsyndi
post Oct 3 2014, 04:54 PM

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Hi Tham,

Thank you very much on the info shared. Appreciate much for your kind help.

I went to Gleneagles KL for Dr. Chee Chee Pin to seek for second opinion since I learnt that he's specialized in Gamma Knife.

But he advised that my case is not suitable for Gamma Knife. I was recommended to remove the tumor by going thru my nasal. Subsequent treatment would be CynerKnife for the remaining tumor which couldn't be removed during surgery.


TSsyndi
post Oct 3 2014, 04:59 PM

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QUOTE(ngaisteve1 @ Oct 3 2014, 01:26 PM)
I think you can request MC from doctor. What doctor's advice for that tumor?
*
Doctor's advice for me is to get operations as soon as possible.

Does it mean that doctor can reject my MC request if i refuse to do operations?
ngaisteve1
post Oct 3 2014, 05:11 PM

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QUOTE(syndi @ Oct 3 2014, 05:59 PM)
Doctor's advice for me is to get operations as soon as possible.

Does it mean that doctor can reject my MC request if i refuse to do operations?
*
I see. maybe is their hospital policy or law
colt45
post Oct 3 2014, 05:38 PM

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Maybe u could go to Sunway medica..Dr. Lee Foo Chang..
I had mine operated through the nasal..


SUSTham
post Oct 3 2014, 07:58 PM

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QUOTE(syndi @ Oct 3 2014, 08:47 AM)
As I believe in human natural healing capability and kentogenic diet (with lots of info reseach), I choose to give myself a chance to go for 3-4 months. It's been 2 months since I was diagnosed with the pituitary tumor and it has not grown as shown in my 2nd MRI results.

My employer has no objection on my long medical leave. They just request me to get MC from doctor. And, I don't understand why neurosurgeon's assistant refused to help me to get doctor's MC when I request so.
*
Isn't the ketogenic diet difficult to follow and may result in malnutrition ?

In children with epilepsy who cannot follow the ketogenic diet, the
modifled Atkins diet, with a higher carbohydrate content and no restrictions
on proteins, works just as well.

http://www.epilepsy.com/learn/treating-sei...ied-atkins-diet



Go and see the neurosurgeon directly, and complain to him that his
assistant has refused to do his duty. She is just an employee there
and has no business to refuse you, nor is it her prerogative to approve
or refuse an MC for you - that is the doctor's right and responsiblity.

The assistant's job is just what it is - an administrative assistant, and her
only responsibility is to let you in to see the doctor, just like any clinic assistant.

If she refuses to do so, tell him that you will lodge a report with the doctor as
well as the medical center.



This post has been edited by Tham: Oct 3 2014, 08:14 PM
SUSTham
post Oct 4 2014, 09:29 PM

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What kind of pituitary adenoma do you have ?

Is it the growth hormone and prolactin-secreting type ?

Read the pathologist's report.



You may well have an anti-aging tumor.

This means that, theoretically at least, if only the tumor did not grow further
and cause problems like compressing your optic nerve, you'd likely outlive
a lot of people.



The following studies are of great interest to life extensionists (like me).


As we age, the thymus shrinks, T-cell production decreases, cellular immunity
follows suit, we become subsceptible to infections like pneumonia and degenerative
diseases like cancer, and ultimately we die.

Implanting pituitary adenoma cells which produce growth hormone and prolactin
into aging rats actually regenerates the thymus, corrects the CD4/CD8 ratio and
restores cellular immunity.



GH3 pituitary adenoma cells can reverse thymic aging in rats.


'' ..... splenocytes from GH3-implanted rats showed augmented T-cell
proliferative responses and increased synthesis of IL-2. ''

'' These data show that it is possible to regenerate normal thymic tissue in situ
and reverse the natural loss in cell-mediated immunity that occurs with aging. ''

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC386349/




Keith Kelley, the principal Illinois University researcher in the above 1986 study,
followed up with this study 27 years later in 2013.

Pituitary epithelial cell implants reverse the accumulation
of CD4-CD8- lymphocytes in thymus glands of aged rats.


'' Thymus glands from old rats contained greater than 50% more CD4-CD8- cells
and a reduced percentage of CD4+CD8+ lymphocytes compared to those of
young rats. Moreover, both of these age-associated changes were reversed
by implanting GH3 cells
. GH3-treated aged rats also had a significantly greater
proportion of CD4+CD8- thymocytes compared to aged control rats. ''

http://www.ncbi.nlm.nih.gov/pubmed/1572290





This post has been edited by Tham: Oct 5 2014, 09:43 AM
SUSTham
post Oct 5 2014, 09:40 AM

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Try the following supplements :


Curcumin
Resveratrol
Lycopene
Beta carotene
Pterostilbene


Curcumin, resveratrol and pterostilbene reduces NFkappaB, or NF-kB.

Resveratrol has poor bioavailability of just 20 percent, a very short half-life
of just 15 minutes and penetrates the blood-brain barrier poorly.

In contrast, pterostilbene has a bioavailabilty of about 80 percent, half-life
of about 2 hours and good penetration of the blood-brain barrier.

Pterostilbene also knocks down NF-kB, but is not a phytoestrogen, however,
so will not decrease prolactin levels.


If you wish to take just one supplement, curcumin is the one for you,
from the studies shown.




Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells.

http://www.ncbi.nlm.nih.gov/m/pubmed/18580810



Lycopene and Beta-Carotene Induce Growth Inhibition and
Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells.

http://www.plosone.org/article/info%3Adoi%...al.pone.0062773



Resveratrol inhibited GH3 cell growth and decreased prolactin level
via estrogen receptors.


http://www.ncbi.nlm.nih.gov/m/pubmed/22104698/



Resveratrol decreases B-cell lymphoma-2 expression and viability
in GH3 pituitary adenoma cells of the rat.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787930/




Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas.

'' Thus, curcumin may inhibit pituitary adenoma progression not only through
previously demonstrated anti-proliferative and pro-apoptotic actions but also
by its suppressive effects on pituitary tumour neovascularisation. ''


http://www.ncbi.nlm.nih.gov/m/pubmed/22739211




Curcumin acts as anti-tumorigenic and hormone-suppressive agent in
murine and human pituitary tumour cells in vitro and in vivo.


'' Altogether, the results described in this report suggest this natural compound
as a good candidate for therapeutic use on pituitary tumours. ''

http://erc.endocrinology-journals.org/content/16/4/1339.long



Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis,
and decreases hormone levels and secretion in pituitary tumor cells.


'' Taken together we demonstrate that curcumin inhibits pituitary tumor cell
proliferation, induces apoptosis, and decreases hormone production and
release, and thus, we propose developing curcumin as a novel therapeutic
tool in the management of prolactinomas. ''

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488238/




Growth suppression of mouse pituitary corticotroph tumor AtT20 cells
by curcumin: a model for treating Cushing's disease.

'' The ability of curcumin to inhibit NFkappaB and induce apoptosis in
pituitary corticotroph tumor cells leads us to propose developing it as
a novel therapeutic agent for the treatment of CD. ''

http://www.ncbi.nlm.nih.gov/m/pubmed/20405005



Curcumin inhibits the growth, induces apoptosis and modulates
the function of pituitary folliculostellate cells.


http://www.ncbi.nlm.nih.gov/m/pubmed/20160430










ahboon76
post Feb 15 2020, 05:58 PM

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Hi.. all.. hope this forum still active. I been diagnosed with pituitary tumor in end of 2018. It started I have this to bitemporal upper quadrantanopia when I do eyes check up. I got a tumor from 3.2cm grow to 4.3cm in April 2019.
Which cause me have double vision. Initially when to Sunway do MRI then Beacon MRI with contrast. Doc Lee suggest me to surgery. Base on MRI I found out that the tumor it too big to do operatio as it too near to Many brand and eyes nerve. It also cover the whole pituitary gland. But Doc Lee insisted me do operation as if not I might have 1-2yrs life.
To cut thing show I when Sunway medical, tungshi, pantai and Thomson. I know I super Kia si... Get so many doc for opinion as my daughter only 7...... So end up I took endocrinology doc advise from Thomson hospital. He ask me do blood test and found my prolactin is way too high. To to reduce it, I been taken cabergoline pill for my treatment. Since April till now. Didn't see and neurology or neurosurgeon. Recently MRI should shine shrinking of the tumor, but my vision still not good. Recently my company change monitor cause me unable read properly and create alot of mess. FYI, my job scope is log case from email and phone. My symptoms are, double vision unable to park my car straight now, mood change very fast. Frequently headach, dizzyness once a blue moon, constipation 5-7days no shit.. weight gain, arm numbness, persistent cough for more and 3mth and which is recently extremely tireless (last mth). I already inform my Endocrinology Dr., He said I'm ok. Yesterday my Bo's already give me written warning letter due to my mistake too frequent that effect my department. I requested number of time to change department and they reject. They want to leave the company. I can't leave due to my children need financial support. Do you think if I visit neurology or neurosurgeon will i able to get long MC since my tumor do show shrink abit.
ahboon76
post Feb 15 2020, 06:41 PM

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QUOTE(syndi @ Oct 3 2014, 04:42 PM)
I'm 32 yrs old. I'm now undergoing the kentogenic diet as recommended by my friend who did not operate removing tumor but heal after 1 month by starting the diet.

I did not have the chance to speak to my surgeon requesting MC as his assistant rejected my request immediately through phone call when she learnt that I refused to do surgery immediately.

I'm puzzled. Should the doctor respect my decision and issue MC according to my condition?
*
How your condition? Is kentogenic diet work?

 

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