Whey Protein Isolate is best to be taken on daily basis. Twice a day is adequate, once before breakfast and another after workout. But it depends on your daily protein intake. Let say you are 65kg, so you need around 140g - 150g of protein. Assuming that you eat 100g of protein from your solid food like chicken, fish and beef, whats left is what you need, so you just need to take like 2 scoop. I suggest you to eat more solid food, than supplement it. For non workout day. is almost the same, morning once and the other is either in between meals or with meals.

For creatine mono, it must be taken before and after workout. For before you can mix it with any juices or isotonic drink and for after you have to mix it with your protein.