Heres some simple refference vdimm
1.8-2.1 = totally safe
2.2-2.3 = safe for 24/7 with proper cooling (ram coolers/ram heat spreaders)
2.4-2.6 = make sure u know what you're doing, eitherway, not recommended for long term usage.
2.6 above = be prepared for damage

Vcore (note, applies to Windsor and Brisbane only)
1.2-1.4 = perfectly safe
1.4-1.6 = temps will rise, make sure adequate cooling is applied.
1.7 > = get prepared for sudden death, dont go over 1.6 if you dont know what you're doing.
And something to add to RAM timings, on my own experience, some chips doesnt like voltage to get good timings.
Overall on ram tweaking, high mhz is pointless if you have to sacrifice timings too much, generally speaking look at refference below.
333mhz (DDR667) = recommended ( cl3-4)
400mhz (DDR800) = try getting within cl4-5 below 2.1v or max cl5
500mhz (DDR1000) = CL5 works good here, if you need to loosen your timing up to cl6, its better to stick to 400mhz. CL4 is recommended for best performance, usually doesnt required more than 2.3v
Generally speaking, RAM performance does give a big boost to AMD systems. It is wise to invest in a good ram as it give noticeable performance boost given that you know how to tweak it. Plus, performance rams are cheap these days, go grab any D9 microns, do keep in mind one thing, lower ram density provides greater overclockability. For example, 512x2 modules will perform better than 1GBx2 in non-intensive memory applications(superPI). Still, it is generally recommended 1GBx2 for overall system performance. I still remember those that that i bought HyperX 256MBx2 for RM600 perkit back to those S478 days

conclusion, find the perfect spot between mhz and timing. and look out for the heat as well.
Added on November 18, 2007, 10:45 pmJust to add some reference temps for newbies
Brisbane core is know to be much cooler than of windsor, therefore temps will vary accordingly.
Take note, regardless of windsor or brisbane, the safe limit is the same. Do not go past 65c on full load. Even 65c on full load is not a very good temp, a healthy 24/7 usage would be below 40 on idle and 60 on full load. Of course, the lower the better. It is wise to invest in a proper cooling, and make sure its a multi-platform compatible HSF as it will be usefull across different platforms and is re-useable in a long term. For newbie, avoid water cooling, it is not adviseable even with those all in 1 kit. It may look good but it far from proper high end water cooling, and maintance is not an easy chore. Recommended at the moment would be Xigmatek 90mm or if you can stretch your budget, try to go for xigmatek S1283, its one of the best performance/price as of now.
And do take note, some am2 motherboards are known to have issue with heat sensors therefore, giving inaccurate results. Keep 1 thing in mind, temps of any components in your computer can never be lower than ambient temps(beside extreme cooling like DI,phase change and in some case, high end water cooling), therefore if your temp readings are way too low, or way too high, the best way to find out is to gently touch the heatsink itself.
For X2 users, you will notice temps difference between the 2 cores, this is normal because each core handles load separately. One may be more active than the other, always take the one with the higher temps as refference.
This post has been edited by AoiNatsume: Nov 18 2007, 11:57 PM