Don't listen to Xaphier. The scroll wheel in the middle can act as middle click. You can also assign the scroll wheel button to work differently using the Logitech Options software.

Source: I had the MX Master 2S for three years and it has been my daily driver for my work.

This post has been edited by SFX: Jan 21 2021, 05:56 PM

MX Master 3 has different side button configuration compared to the 2S. If your thumb is big, you might accidentally click the side buttons on the 2S as they are on top of each other.

I use the side buttons for Window's File Explorer to navigate around folders.

I suggest you to try out both 3 and 2S physically in-store, if possible, to check your needs.

For me I'll go with 3 for its USB-C support. Don't need to fiddle around with 2S' micro-USB cable when I want to charge my mouse.

The new tech scrolling wheel is not 3 exclusive. Both 2S and 3 has hyper fast scrolling.