if your mobo is the same, then it should be any problem.

for example, if you r using dell optiplex 230, u can ghost (clone) it to a new HDD, and when ur workstation having problem, then u can use your backup HDD to restore it. However, if you r using optiplex 230 and you want to retore ur backup HDD to a acer, then it wont work.

Ghost is more for those lazy admin to setup a simple workstation in a easy way. I was one of them