Browsers people use often matters to preferences.
I've been using chrome for at least 3 years and I'm very very used to it.
It syncs all of my settings, including saved passwords for easier login and even browser theme to my google account, makes life easier for me.
There's still some cons, such as the lack of NPAPI support, higher RAM usage and more processes.
I don't use Firefox since I'm not familiar with the settings and the layout, my friend use it however since he said Chrome uses too much of his RAM.
Honest opinion is that if you have big RAM and fast CPU it doesn't really affect anything...
I used Opera back in my 512mb RAM desktop days since it's lightweight, loading time however is noticeably slower.
Ehh... doesn't really matter even if you have even the best browser in the world, it's still slow if your internet is crap XD