Too much protein may cause reduced kidney function
Researchers at Brigham and Women's Hospital (BWH) have found that high-protein diets may be associated with kidney function decline in women who already have mildly reduced kidney function. On further analysis, the risk was only significant for animal proteins, indicating that the source of protein may be an important factor. Researchers observed no association between high protein intake and decline in kidney function in women with normally functioning kidneys. These findings appear in the March 18 issue of Annals of Internal Medicine.
The data suggested that the type of protein consumption was also an important variable. A change in GFR was only significant among women consuming large amounts of nondairy, animal proteins.
"Recently, we have witnessed a growing popularity in low-carbohydrate, high-protein diets," said Knight, also of Harvard Medical School and Massachusetts General Hospital. "As millions of Americans experiment with these diets and protein supplements, caregivers and researchers continue to question what the long-term health outcomes will be. While many questions still remain unanswered, we certainly have some evidence that among women with reduced kidney function, these diets may have adverse effects."
It has previously been hypothesized that high-protein diets adversely affect the kidney because of the stress required to process proteins. Increased protein consumption leads to hyperfiltration - a state in which the kidney faces increased pressure in order to filter and remove waste from the body. Over the long term, hyperfiltration may lead to kidney damage.
http://www.news.harvard.edu/gazette/2003/0.../09-kidney.html
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