I used TX-3 for FX-8350 - it's HOT. No kidding, with vcore boost and all it will be really really really hot.

Currently using AIO setup for my FX-8350, non-OC.

You can forget about 4.5ghz using TX-3 though, unless you don't mind running it at the brink of breaking down due to overheat.

Realistic figure with TX-3 probably goes to around 3.5ghz to 3.8ghz range with some vcore boost.

Whether it's CM Seidon or Nepton, it would do a lot better than the TX-3.

As for the graphic, it shouldn't have such problem as that one's a matter of your R9 280X which would not be affected by your overclock.