Be positive always and never loose hope.

Well, it's good that the Selayang surgeons believe they can remove your tumors.

As for radiotherapy, ask them if they have the newer machines like Tomotherapy,
Trilogy or Elekta Synergy. Those are more precise and subject the surrounding tissues
to less radiation.

Places like Subang Jaya, Mount Miriam, Nilai and Pantai have these machines, but
treatment won't come cheap.


After your surgery and radiotherapy, I would strongly suggest that you start on the
supplements I have told you about, or any other form of adjuvant treatment like TCM.

This is because even after the tumor has being removed or radiated, the underlying
biochemical and genetic signalling pathways which stimulated the growth of the
cancer cells in the first place - are still there.

The mechanisms which causes the growth of NF2 benign tumors also appear to be
culprits behind NF1 benign and malignant tumors, particularly PAK1 and mTOR.

Thus, if you can block or suppress these pathways - you will stop or at least slow
down the growth of the tumors.





This post has been edited by Tham: Nov 5 2014, 09:22 PM

Mechanisms in the pathogenesis of malignant tumours
in neurofibromatosis type 1.

'' Several pathways are thought to be involved in the development of tumours
associated with NF1: rat sarcoma viral oncogene homologue (RAS)-mitogen
activated protein kinase (MAPK), mammalian target of rapamycin (mTOR), and
P21 protein (Cdc42/Rac)-activated kinase 1 (PAK1). ''


http://www.ncbi.nlm.nih.gov/m/pubmed/19410195



Effective neurofibromatosis therapeutics blocking the oncogenic kinase PAK1.


'' In other words, dysfunction of NF1 gene (causing type 1 NF) is basically the same as
dysfunction of NF2 gene (causing type 2 NF). In fact the growth of both NF1 and NF2
tumors requires PAK1, and all PAK1 blockers, synthetic chemicals or natural products,
suppress the growth of these NF tumor cells both in vitro (cell culture) and in vivo (mice). ''

http://www.ddtjournal.com/action/downloaddoc.php?docid=482

http://www.ddtjournal.com/getabstract.php?id=482



A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor.

'' These results suggest that PAK1 is essential for the malignant growth of
NF2-deficient cells, and that PAK1-blocking drugs could be potentially
useful forthe treatment of neurofibromatosis types 2, in addition to
Ras-induced cancers and neurofibromatosis type 1. ''

http://www.ncbi.nlm.nih.gov/m/pubmed/15000491



CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses
the growth of human neurofibromatosis (NF) tumor xenografts in mice.

http://www.ncbi.nlm.nih.gov/m/pubmed/18726924/




Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic
PAK1 signaling and suppresses the growth of NF tumors in mice.

http://www.ncbi.nlm.nih.gov/m/pubmed/19003952

Neurofibromatosis Type 1 and tumorigenesis:
molecular mechanisms and therapeutic implications.


'' Multiple key pathways are involved with the development of tumors in NF1,
ncluding Ras/mitogen-activated protein kinase (MAPK) and Akt/mammalian
target of rapamycin (mTOR). ''

'' In general, for malignant transformation to occur, there must be accumulation
of additional mutations of multiple genes including INK4A/ARF and P53, with
resulting abnormalities of their respective signal cascades. ''


'' Finally, increased knowledge of molecular and cellular mechanisms involved
with NF1 tumorigenesis has led to multiple preclinical and clinical studies of
targeted therapy, including the mTOR inhibitor rapamycin, which is demonstrating
promising preclinical results for treatment of MPNSTs and gliomas. ''

http://www.ncbi.nlm.nih.gov/m/pubmed/20043723




Expression of insulin-like growth-factor-1 receptor (IGF-1R) in
peripheral nerve sheath tumors in neurofibromatosis type 1.


'' NF1 is the most frequently inherited disease associated with a predisposition
for cancer (in particular malignant peripheral nerve sheath tumors: MPNST). ''

'' This investigation provides evidence for the expression of IGF-1R in nerve
sheath tumors in NF1.

The first evidence for IGF-1R expression in mutated Schwann cells may
indicate a tumor-type associated receptor expression in NF1. ''

http://www.ncbi.nlm.nih.gov/m/pubmed/17649826/



The common NSAID, celecoxib (Celebrex), which has very unique
anticancer activity, blocks IGF-1 and IGF-1R.



Celecoxib inhibits insulin-like growth factor 1 induced growth
and invasion in non-small cell lung cancer.

'' Celecoxib inhibited IGF-1-stimulated growth and invasion in a dose-dependent manner.
Celecoxib also reduced the expression of IGF-1R, IGFBP-3 and phosphorylation of AKT.
The results suggest that modulating the IGF axis may be a new mechanism for the
anticancer effect of celecoxib on NSCLC. ''


http://www.ncbi.nlm.nih.gov/m/pubmed/23833672/





Moreover, COX-2, as in many cancers, is overexpressed in NF1,
and celecoxib is of course a COX-2 blocker.


Overexpression of cyclooxygenase-2 in malignant peripheral nerve
sheath tumor and selective cyclooxygenase-2 inhibitor-induced
apoptosis by activating caspases in human malignant peripheral
nerve sheath tumor cells.


'' Overexpression of COX-2 (≥50% positive cells) was observed in 29 cases (65.9%),
was significantly associated with a poor overall survival and was considered an
independent risk factor for a poor outcome ..... ''

'' Selective COX-2 inhibitors including etodolac had an antitumor effect on
MPNST cells, and their use holds promise as a novel therapeutic strategy for
patients with MPNST to improve their prognoses. ''


http://www.plosone.org/article/info%3Adoi%...al.pone.0088035

http://www.ncbi.nlm.nih.gov/m/pubmed/24516579/



Etodolac is an older generation drug, less selective for COX-2 than celecoxib.


You can buy Celebrex at any pharmacy, about $3 a capsule, 200 mg.

I still have a few caps in my office drawer. Half a cap, 100 mg, will knock
down any fever far faster than paracetamol.






This post has been edited by Tham: Nov 6 2014, 07:46 PM

Not to forget about Bee Pollen too - the world's most perfect and complete health food which has more than 200 nutrients and natural

http://www.livestrong.com/article/544691-b...len-for-cancer/

http://www.webmd.com/vitamins-and-suppleme...uide-bee-pollen

http://www.drugs.com/npp/bee-pollen.html

http://www.thesuperfoods.net/bee-pollen/be...llen-for-cancer

In laboratory experiments conducted on lab mice several decades ago, Dr Robinson studied the effect of bee pollen on tumors. The laboratory mice were bred to develop tumors. Once they did so, they were divided into two groups. One group was fed regular mice food and the other was given bee pollen in addition to the food in a ratio of 1:10,000 bee pollen is to food. It was found that 100% of all the untreated mice developed mammary tumors at the expected time. Of the other group fed bee pollen, some develop similar tumors but after a delay of around 9.8 weeks and 7 out of the group did not develop any tumors until the tests ended after 62 weeks. It was concluded that the mice without bee pollen died at the expected time.

Another study conducted on 25 women with uterine cancer was undertaken in the University of Vienna. These women could not undergo surgery and were only being treated with chemotherapy. A few were given bee pollen in their diet and quickly developed greater antibody production, greater amounts of immune-system cells that fight cancer and red blood cells that can fight infections. They also suffered less of the dreadful side effects that accompany chemotherapy. Their hair loss was minimal and they suffered less nausea symptoms. Hence, these women also suffered less from insomnia. The group that did not receive bee pollen did not have the same relief.

Bee pollen does not have CAPE, artepillin and other compounds present in
propolis, which you need to block the PAK-1 gene in NF1 and NF2 tumors.








This post has been edited by Tham: Nov 6 2014, 09:26 AM

Sichuan pepper extracts block the PAK1/cyclin D1 pathway
and the growth of NF1-deficient cancer xenograft in mice.


'' Unlike FK228, these extracts do not inhibit AKT activation at the concentrations that block either cancer growth or PAK1 activation.

The Chinese pepper extract selectively inhibits the growth of NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
cells, without affecting the growth of normal fibroblasts, and suppresses the growth of NF1-deficient human breast cancer (MDA-MB-231) xenograft in mice. Our data suggest that these peppercorn extracts would be potentially useful for the treatment of PAK1-dependent NF such as MPNST, in addition to a variety of PAK1-dependent cancers including breast cancers. ''


http://www.ncbi.nlm.nih.gov/m/pubmed/16418572



http://gernot-katzers-spice-pages.com/engl/Zant_pip.html




Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of
the AKT and AR signal pathways.


http://www.ncbi.nlm.nih.gov/pubmed/16685399




This post has been edited by Tham: Nov 6 2014, 09:14 AM

Just an update, i just got discharged from the hospital and the manage to successfully removed the tumour , im not cancer free yet, still have to wait for the lab results on the tumour to get come back and then see whats the next course of treatment.

Glad to hear you had it removed. Keep us posted on the results, have plenty of rest.

Good to know that your operation was a success.

Take care.

Good to hear that. Ya update us from time to time

I think you will need to take chemo medicine right? Because my friend after the operation will need to take chemo medicine.

Get well soon.

who is the doctor that helped you in removed the tumour ?

Thank you guys for the support,
so far waiting for my incision to heal then wait for the next doctors appointment and from them know whats my next course of treatment.

Dr Krishnan was my surgeon, hes seriously a good doctor. *thumbsup*

Any updates on your situation ?

I am keen to know the outcome

Thank You