Had spotting since week 6 - doctor prescribed Duphaston as well. Started with 1 tablet per day for first few weeks, until one day, fresh blood gushed out after sneezing. Doctors diagnosed that I was having a threatened miscarriage (most of the spotting cases when they cannot explain why the bleeding occurs, it is referred as a "threatened miscarriage". At that moment, I was put to complete bed rest with 4 tablets of Duphaston daily.

Then, bleeding reduced, and they reduced the dosage to 2 tablets / day until week 16.

Again, diagnosed with cervical thinning and premature contractions at week 26, been on complete bed rest again until now (week 33). Took steroid jabs to help baby's lungs inflate in case I go into labor early.

I personally feel that it's not Duphaston's side effects. My advise is, take lots of rest, and even if she has got no appetite, make sure that she takes at least some milk / soda biscuits.

In case if anything happens, feel free to get a second opinion from another gynae.