The number one best way to get someone to look at your resume closely: come across as a human being, not a list of jobs and programming languages. Tell me a little story. "I've spent the last three weeks looking for a job at a real software company, but all I can find are cheezy web design shops looking for slave labor." Or, "We yanked our son out of high school and brought him to Virginia. I am not going to move again until he is out of high school, even if I have to go work at Radio Shack or become a Wal*Mart greeter." (These are slightly modified quotes from two real people.)

These are both great. You know why? Because I can't read them without thinking of these people as human beings. And now the dynamic has changed. I like you. I care about you. I like the fact that you want to work in a real software company. I wanted to work in a real software company so much I started one. I like the fact that you care more about your teenage son than your career.

I just can't care about "C/C++/Perl/ASP" in the same way.

So, maybe you won't be qualified for the job, but it's just a lot harder for me to dismiss you out of hand.