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 CALLING ALL MEDICAL STUDENTS! V2, medical student chat+info center

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lovey_doveygirl
post Nov 25 2009, 11:34 PM

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QUOTE(nicodemus88 @ Nov 25 2009, 01:09 AM)
I have a question here but I couldn't find the answer... Could someone explain this to me?

Wernicke's encephalopathy is caused by thiamine deficiency... And thiamine is an important cofactor of enzymes involved in carbohydrate metabolism... Patient's with WE or sub-clinical thiamine deficiency will have exacerbation of the encephalopathy when they take carbohydrate... Why does this happen? How intake of carbohydrate in people's with thiamine deficiency will cause neuro symptoms?

From what I understand, thiamine deficiency causes damage to the neuron, mainly in thalamus and also mamillary bodies of hypothalamus. Also low levels of thiamine cause impaired carbohydrate metabolism leading to increase glutamate in the brain, leading to gliosis. So the neuronal damage could be said as gradual... So how does intake of carbohydrate in thiamine deficiency patients exacerbate the neuro symptoms?

Thanks!
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perhaps patient is also taking alchohol at the same time...

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