i use epiphone les paul 100 MIK..and use line 6 pod xt live..steel use original pick up. influence muse sound..any one can suggest for better tone 4 my sound??

Probably Seymour Duncan '59s or perhaps a Jazz/JB combo....
But the problem with the LP-100, is that it doesn't have THAT fantastic tone and most pickups installed would be just a moot point.
I have EMG 81/85s installed in my LP-100, only because they are super high powered and can basically turn any guitar into a power house. However, tone-wise might be a little too sterile if you're into Muse.......

What amp do you use?

well, apart from changing the pickups, it depends on wat amps u use....even with a powerful tool like the POD Xt Live (which i have one myself), its not gonna turn a shitty amp into a Triple Rect or Bogner Ubershall or Marshall....to really feel the power of the POD Xt Live u'll have to play it on at least a decent amp....thats why if at home i'll just use my headphones to play because u get a better idea on the amp modelling of the POD....