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Life Sciences The PHARMACY Thread, everything you need to know/ask

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polaris91
post May 30 2011, 03:49 PM

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did you mean ATAR of 85 ? frankly speaking that wasnt really impressive tho :/
polaris91
post May 30 2011, 03:52 PM

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at least 90 for pharmacy school in australia..
polaris91
post May 30 2011, 10:38 PM

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QUOTE(baoz @ May 30 2011, 09:51 PM)
I'm in Year 3, but this pharmacokinetics stuff I learnt back in Year 1.
EDIT:

Ok, I just re-read your question The answer is incorrect.
For rapidly dissolving oral dose forms of a drug

- here the situation says we have a drug that is rapidly dissolving. so drug dissolution is not a rate-limiting factor.
differences in rates of dissolution markedly affect the plasma concentration-time profile,

- this is true. if a drug dissolves quickly, it goes into the plasma quickly and vice versa.

when intestinal permeability is the rate-limiting step

- this is where it gets wrong. once intestinal permeability limits the rate of your drug getting into plasma, it doesn't matter if your drug dissolves quickly or slowly because it is being held up by the intestinal wall. this sentence makes the second sentence wrong. only when intestinal permeability is NOT the rate-limiting step then differences in rates of dissolution will markedly affect the plasma concentration-time profile.
Just imagine a highway toll where there's no Touch&Go or Smart Tag. You have lots of cars jammed up (highly dissolving drug) behind the toll gate(intestinal permeability). The amount of cars getting through (into plasma) will not change unless you alter the toll gate to work quicker.
Once you get hold of this concept, you can refer back to my previous post on sink condition to know what happens once the cars move past the toll gate. I'm guessing you'll learn about this at a later chapter. smile.gif
*
GOTCHA !!! biggrin.gif are you those kind of HD average students in pharmacy ohmy.gif i have heaps questions to ask though tongue.gif
btw what uni do you attend ? you guys learnt PK in first year ??
i learn PK in a unit of study called therapeutic principles which is basically a mix of PK,PD,pharmacogenomics, pharmacoepidemiology etc etc..it was suppposed to be taught separately in 2nd year 2nd semester and 3rd year but since the faculty has implemented a new curriculum so we have to learn it in 2nd year :S

polaris91
post May 31 2011, 09:57 AM

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QUOTE(baoz @ May 31 2011, 08:57 AM)
@polaris : aha no lar not average HD.. just that this is my favourite topic in pharmacy so I know it pretty well. smile.gif You can shoot some questions but I can't guarantee I can answer them all. sweat.gif

Our curriculum is quite different from yours.. we learn in streams.. We have four streams where we learn over our 4-year course. This PK and PD stuff fall under the Drug Delivery stream. So we start with the basics in Year 1 and Year 2 and we use that knowledge to apply to stuff we learn in Year 3 and so on. And in Year 3 onwards we start to see them all come together in different units. Sort of getting "integrated". smile.gif

You can check out our course outline HERE.
@zstan : yeah. year 1 sem 2 under the unit Drug Delivery I.
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well i rckn we have a really really different curriculum lol...the faculty introduced this since 2009 so it`s relatively new..
the old students used to learn med chem and bio chem in late 2nd year but now we learn it first year and second year under DDDA..thats killing me
http://sydney.edu.au/handbooks/pharmacy/un..._of_study.shtml

yeh definitely...id throw you heaps questions from my past papers since i dont have the answers biggrin.gif
polaris91
post Jun 1 2011, 12:08 AM

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QUOTE(zstan @ May 31 2011, 10:40 AM)
ermmm.. why don't you consult your friends? unsure.gif
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ive asked heaps but no one seems to be sure for the answers :S
so i reckon this is a great platform for me to get some confirmation
polaris91
post Jun 2 2011, 08:32 PM

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QUOTE(baoz @ Jun 2 2011, 08:19 PM)
That comment is a little uncalled for.. We're here to share and not to boast or thumb others down..

@polaris: usually if more than one person doesn't understand a concept, it'll be good to participate on your blackboard discussion/forum or email your lecturer about it (or make an appointment to consult directly) because then the lecturer will clarify the concept again during the next lecture. Active learning!

@Cheryl: communicating with patients and colleauges plays a big part in pharmacy. We are actually trained in university on how to talk to patients. The right body language, the right words, the right tone, the way you greet your patients. In hospital and community, talking to patients actually makes up the core of your job. No communication, no serving patients.
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nah apparently the discussion board on bb/webct is dead lol...we dont really use it though..
and our coordinator for this unit has gone :S fml
polaris91
post Jun 2 2011, 08:48 PM

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alright i just got another question here:

10. As team leader of the preclinical development division of a complementary medicines company, you have been asked to identify and characterize the potential for transporter mediated drug- drug interactions which could limit the successful use of a novel lead compound formulated for oral administration. You approach this by

(A) requesting your research staff to investigate this by employing the use of the human intestinal cell model to characterize drug flux in vitro

(B) requesting your research staff to investigate this by using a microvascular brain endothelial model to simulate drug flux across the blood brain barrier

© requesting your staff to recruit healthy volunteers and assess the area under the plasma time curve after oral administration of hypericin

(D)Examine the potential for drug-drug interactions using a cell line over expressing the C3435T MDR1 polymorphism

(E) C and d are both correct


*since the drug is formulated for oral admin...there`s no point of testing it using a brain endothelial cell model so i reckon B is wrong..
and I dont think C is correct too because St johns wort induces the expression of p-gp and cyp3A4 which limits bioavailability..
so now im not sure whether D is correct but i rckn A sounds right since it is using the intestinal cell

polaris91
post Jul 21 2011, 08:10 PM

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new semester is commencing soon =S

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