I'm using AntiVir Personal AV, ZoneLab, and Ad-Aware SE.

Life has been better since i used it. Especially with the combination of AntiVir AV & Ad-Aware. Both software seem to work well. Whenever i fun Ad-Aware to scan for adware, AntiVir would automatically detect the file and promptly ask the user to delete or quarantine.

ZoneLab is also a good firewall s/w. But sometimes it can cause my PC to hang.