Bought the game Operation Creature Feature from US PSN store today and encountered loading screen hang problem. Checked online and found out the game is region locked! It doesn't play on Asian PS3 if you bought the game from US PSN store.

WARNING: Make sure to check your PS3 region and PSN store region before purchasing any PSN Eye games. I've just dump USD 5 into the drain.

It depends, some do have "region lock". E.g. Operation Creature Feature from US PSN not playable on Asia PS3. Some are tied to the region of the game (e.g. COD4 Map Pack download from US PSN only playable with COD4 region 1)

Usage of PS Eye:

1) PSN Downloadable PS Eye game
2) Limited PS3 game supporting PS Eye in some form (Eyes of Judgement, Burnout Paradise etc)
3) Video chat (it comes with own built-in mic)

So you can evaluate whether it's worth it or not