actually it is not easy to cut, if you cut 3mm ACP then yes, you can use those large hand blade to cut

usually cabinet come with backing + ACP as surface, 3mm ACP alone wont be enough for cabinet door, even though it is plastic, it can be difficult to cut

i've tried to cut those high density foam board before, in the end i just give up and use jigsaw instead

if you want to do a cutout like this, but the grill first then measure the cutout size, the cutout size is actually smaller than the grill dimension