I have done my result into this subject. Just want to share in layman terms:-

1. Glucosamine Sulphate (GS) is the basic component of the cartilage. GS will produce the matrix of the cartilage including the fluid or you call it the lubricant in between the cartilages. Sulphate acts as a glue to bind the GS

2. Chondroin sulphate (CS) is a polymer of GS. The molecule weight for CS is 10,000 dalton and above whereas, GS is 456.62 dalton. Many GS makes CS. In simple term, CS is Sugar, GS is Glucose. If you take sufficient GS, there is no need to take CS, because eventually CS will be broken down to GS in the intestine and the huge molecule makes it difficult to be absorb. So, do you take a flight or drive to Singapore?

3. Recent studies show that sometimes arthritis (Osteo) affects the bone, Combination of GS + CS have some effect on preventing accessive bone breakdown which affects Arthritis.

4. Numerous studies show that 1500mg/daily of GS is sufficient to help on pain relieve and in long run strengthen the cartilage.

5. If you take a proven brand, you will get a pain relieve as soon as 2 - 4 weeks. You will also feel relieve of other symptoms such as the cracking sound on the knee, stiffness on the knee joint in the morning,

6. Transdermal GS is not effective because the absorption rate is very weak.

Good luck and speedy recovery~!