1. Clear Mission 11 in Human Mode
2. Clear All missions in Human Mode
3. Clear Mission 11 in Devil Hunter Mode
4. Clear All Missions in Devil Hunter Mode
5. Clear Mission 11 in Son of Sparda Mode
6. Clear All Missions in Son of Sparda Mode
7. Clear Mission 11 in Dante Must Die Mode
8. Clear All Missions in Dante Must Die Mode
9. Clear All Missions in Heaven or Hell Mode
10. Clear All Missions in Hell and Hell Mode
11. Clear all Missions in Human Mode with an S Ranking
12. Clear all Missions in Devil Hunter Mode with an S Ranking
13. Clear all Missions in Son of Sparda Mode with an S Ranking
14. Clear all Missions in Dante Must Die Mode with an S Ranking
15. Clear all Game Modes
16. Clear all Secret Missions
17. Clear stage 10 of Bloody Palace Mode
18. Clear stage 20 of Bloody Palace Mode
19. Clear stage 30 of Bloody Palace Mode
20. Clear stage 40 of Bloody Palace Mode
21. Clear stage 50 of Bloody Palace Mode
22. Clear stage 60 of Bloody Palace Mode
23. Clear stage 70 of Bloody Palace Mode
24. Clear stage 80 of Bloody Palace Mode
25. Clear stage 90 of Bloody Palace Mode
26. Clear All Bloody Palace Mode stages
27. Clear All Bloody Palace staged with an S Ranking
28. Clear the game with Super Nero (Dante)
29. Complete a Stylish Rank S (Smokin'!) combo
30. Complete a Stylish Rank SS (Smokin' Style!!) combo
31. Complete a Stylish Rank SSS (Smokin' Sick Stlye!!!) combo
32. Complete a mission with an S Ranking
33. Extend the Vitality Gauge to maximum capacity
34. Extend the Devil Trigger Gauge to maximum capacity
35. Acquire 10,000 Red Orbs
36. Acquire 100,000 Red Orbs
37. Acquire 1,000,000 Red Orbs
38. Acquire 10,000 Proud Souls
39. Acquire 100,000 Proud Souls
40. Acquire 1,000,000 Proud Souls
41. Defeat a total of 100 enemies
42. Defeat a total of 1,000 enemies
43. Defeat a total of 10,000 enemies
44. Acquire a maximum number of all items
45. Acquire all of Nero's skills
46. Acquire all of Dante's skills