For music that does not require much bass, I go for S1000DB.

If you play music that has lots of bass + gaming/movie with explosions/boom (call of duty?), I go for S350DB.
If lack of desktop/table space, I go with S350DB too.

So depends on which activity you do the most (see above).

For me, I do video editing, I use Edifier R2730DB Studio Monitor speakers. This speaker is not so great compared both of these speakers above in terms of high.

Edifier S350DB 2.1 Speaker system is definitely much better for overall usage (watching movies/tv-drama, listening to music, audiobook)

For audio editing purposes, go with Studio monitor which is Edifier R2730DB (it gives a balance tone, not a lot of highs and not a lot of bass).

It's based on your usage though, what activities do you use your speakers for? 

for your information: Edifier has released S360DB, a better version of S350DB which uses a better tweeter, slightly wider mid-range drivers and the subwoofer is wireless (can enable/disable if you are not so much of a bass person). = RM500+ extra for those new features.

Edifier C3X is an affordable decent 2.1 speaker system. If you have the budget and the Edifier S350DB is available in your country, I would recommend you to get the Edifier S350DB instead of Edifier C3X as it delivers much more powerful deeper bass and mellow-smooth highs. If your country have a speaker shop, I would advice you to audition those speaker to see which 2.1 speaker system suits your preferences.