The Football Association announced at 13:00 GMT today (Friday) that Chris Smalling has returned to United from the England camp due to injury. The Reds centre-back follows his club colleague Phil Jones in having his international stint cut short and he'll be replaced in the squad by Middlesbrough's Ben Gibson.
Defenders Chris Smalling and Phil Jones suffered "long-term injuries" while on duty with England, says their Manchester United boss Jose Mourinho.
Jones, 25, picked up a toe injury in an innocuous training ground tackle, with reports claiming it involved Smalling.
And fellow centre-back Smalling, 27, was pictured with a leg brace following an injury also suffered in training.
Defender Axel Tuanzebe, 19, who has made one United appearance is in the squad to face West Brom on Saturday.
United will also be without striker Zlatan Ibrahimovic and midfielder Ander Herrera, who are both suspended, and France midfielder Paul Pogba, who has a hamstring problem.
Asked how long he expects to be without Jones and Smalling, the United boss said: "I don't know, I don't know.
"I know that Zlatan and Herrera have the last match ban, so it's easy to say they will be available after the match.
"I think clearly the two English boys they are long-term injuries and Pogba I have no idea. I don't know."