All effective virus and trojan will evolve because antivirus will catch up with their threat. Hence, you will need a better detection that can even detect evolved trojan, virus or even encrypters. But their payload process are quite similar. This is where Dr.Web ave Origin Tracing and Heuristic Analyzer to do the magic.

Which ever way it evolved, the virus will have similar payload. Origin Tracing will detect how those virus behave and how the payload works, compare to the database of virus with similar payload and voila! it kills it before it ready to drop the payload