Try using Google DNS and lipot back

There's something wrong either with TM or Twitch HK01 (Hong Kong?) CDN.
My bet is on TM because some other website also sometimes slow to load.

I found a temporary solution but you need "Twitch Buffering Fix" Chrome extension and switch to Seattle CDN server. It's already removed from Chrome Web Store, but you still can find it on Github.

Maybe safe, I guess~ I got it from Web Store before it was taken down. But you can try my modified version below, if you still need it.
I always use Google DNS, but yesterday issue got nothing to do with DNS. But since last night everything seems to be back to normal.

By the way, I made some modification to the original Twitch Buffering Fix extension. Even on 8mbps Streamyx, usually I'm unable watch Source quality on our default Twitch CDN (Hong Kong). But then I found the address for Tokyo CDN and so far in my test, I'm able to watch most of Twitch stream in Source quality. But of course Source quality still depends on many variables such as how the streamer set their bitrate and stuff. So if it works, then good. If not, just switch to High quality~

So for those using Streamyx 8mbps, give it a try : http://www.mediafire.com/download/efvrvp58...%5D+1.0.5.1.crx

Changelog :
1.0.5.1
- Add Hong Kong server
- Add Tokyo server
- Add storage permission to remember the last selected server
- Add white background to the icons