Hi Tham,
It's actually quite good to have a discussion with you. Provided we stay civil and not call each other 11 year olds with kindergarten education.. haha
Anyway, with no offense, I think you misunderstand how a double blinded trial works.
Both patient and investigator don't know whether the patient is receiving the placebo or the actual drug. It is the only way to control to placebo effect. Without testing drugs this way, there is no way to know if your drug/treatment is effective.. then we will be back to age of snake oil and witch craft... basically you can claim anything works without needing to prove it.
However, we are talking about proper diseases here such as cancer. And claiming that clinical trials are useless and idiotic means you don't buy into one of the founding principles of modern medicine - Evidence based medicine.
To put into perspective, some traditional medicines have been around for thousands of years... yet life expectancy has nearly doubled in the last 100 years only with the advent of modern medicine.
you are right, placebo effect is significant , especially in functional disorders. Which is why you must exclude it, otherwise we'd be treating patients for no reason when all they need is a sugar pill. I use a mild placebo with reassurance sometimes for cases which i know are psychological, and presto , they feel better.
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And throwing drugs/placebo away is ''statistically insignificant'' ?
in a double blinded study it can be controlled for. Example, If both arms have a 15% non compliance rate and they are blinded to the placebo / drug, then statistically it doesn't matter. The odds of placebo dropouts and actual drug dropouts will be the same, assuming your sample is big enough and evenly matched. Doing a good trial is not easy. Many trials are rejected from Q1 journals because they have too much bias. If you want to publish in low ranking journals then they tend to be less fastidious.
Ultimately, despite all these complementary medicines, when proverbial shit hits the fan, and they come down with a severe illness they still end up coming to major hospitals seeking treatment.
Anyway, Tham, i respect your passion for Vit C and its been great having this discussion. I will certain keep my eye out on this subject and in the event I get asked this by anyone else at least I will have some insight into it.
I only came to add an opinion, not to argue or convince anyone. I don't have time to respond anymore, but if you would like we can discuss in private someday.