use higher iso if shot taken indoors/low light condition.
use view finder, tuck your elbows to your body to minimise hand shake.
use faster shutter speed
use flash
these are just some suggestion, feel free to try and workout the best way.
cheers.

why u want to use manual focus?
the AF can't lock on the target?
u won't get a precise manual focus if u don't have those split type focusing screen.

I put it on the table to snap...then it is very clear...

If you don't have a tripod, hold the camera with both hands and steady it by leaning and bracing yourself against a wall, tree or pole, car roof, anything. You can also hold your camera in both hands and brace your elbows against your body.

Another way to help minimize camera shake is to use the viewfinder instead of the LCD when composing shots. Bracing the camera against your face helps steady it.

Digital cameras are more prone to camera shake when taking hand-held shots and zooming in on a subject. To help prevent blur, shutter speed should be set faster than the focal length. For example, a lens set at 200mm (35mm equivalent) requires a shutter speed of at least 1/200 second.

http://www.digicamhelp.com/taking-photos/c...amera-shake.php

why u want to use manual focus?
the AF can't lock on the target?
u won't get a precise manual focus if u don't have those split type focusing screen.

Yeah, I also tried Manual focusing on compact cams ... I laugh like crazy after so many shots taken handheld were blurry

I thought to myself "I am a big huge sucker for compacts, better shut-up and use my SLR better" 

Put it this way ... compacts' MF and SLR MF is totally different. Compacts' MF is still very much 'Auto' becoz you cannot twist the lens like you can a SLR.

Oh, yaya, still digital navigation...not twisting the  lens

Yalah ... after try a few time going back and forth I laugh like hell. Try this models also cannot, that model also cannot. But I think the funniest ones are not the compacts, but the semi-pro ones. Imagine, with the EVF I can't even see if my subjects are in focus or not!

iso=how fast the light is captured
shutter=the time the light has to be captured by the ccd/cmos sensor/film

i thought ths iso is the sensitivity of the CCD/CMOS sensor to light?
and shutter speed is how long the shutter open?

i read from the web lanevoX gave....
noise is reduceable by softwares... how well will the reduction be? can it be perfect no noise?? i tried using PS.... not so ez... many options to do.... confusing.... auto reduction seems ok... but some time still can see noise... confused~

high ISO wont create noise? my DC if switch to highest ISO (400) alot of noise appear... especially when indoor with low lighting condition....
ISO speed and shutter speed... any diff?

just wonder how to solve this. if use flashlight the photo will not be natural i mean the face of the person isn't that " 3d" become mroe flat something like that. how to solve this?