Could it be carpal tunnel? Check with a doc by all means.

But before settling for surgery, try out those chinese metal balls you can use to roll around on one hand. Some guy with carpal managed to cure himself with this.

After you get cured, invest in ergonomic mouse and keyboards.

If it's not carpal, I fear it may be a problem related to nutrient deficiency. Either that or you used to practice karate on bricks.