if you liked bass then the Altec will win no matter how it sounds as R1280T isn't bassy in computer speaker range

but since R1280T doesn't have the generic bass of average computer speaker, it won't have bass mudding it's sound

but lets say I were to switch off the VS4621 subwoofer and only compared the two stereo speakers,

The R1280T is extremely full sounding with body and texture compared to the dead plastic sound of VS4621 down firing midranges