Is this thread created to share peer-reviewed studies related to age-based mental decline?
If so, general or specific into prevention and recovery?
Alzheimer's, Dementia and Aging
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 Nov 28 2013, 05:33 PM
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Nov 29 2013, 02:45 AM
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QUOTE(Tham @ Nov 28 2013, 10:54 PM) Both. General info, peer-reviewed or anecdotal reports, on any form of dementia I understand.- cognitive decline and senility in old age or from diseases like heart failure and diabetes, as well as specific into Alzheimer's, vascular dementia and related degenerative diseases. What helps to improve cognition and memory (''smart'' drugs and nutrients) will also generally help Alzheimer's and dementia. I posted a lot of these studies on the local Alzheimer's Foudation's forum and blog some years ago, as well as linked them to the thread in the Immortality Institute's forum, but they deleted them all. Apparently they are sponsored by the drug firms, so naturally did not take kindly to outsiders suggesting supplements and herbs.  |
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Nov 29 2013, 04:19 AM
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Let's go through the studies and news per category, and now I may research upon preventive measures as for convenience.
By studying the causes or the matters that exacerbates dementia or Alzheimer's, we can draft out a plausible preventive measure, or assumptive solution. Correcting high blood pressure High blood pressure is cited by two studies as to exacerbate dementia. QUOTE "The precise reasons why high blood pressure might increase the risk of dementia are not fully understood although many scientists believe that it can starve the brain of bloodflow and the oxygen it carries. Patients suffering this restricted bloodflow are often described as having "vascular dementia", and account for approximately a quarter of dementia patients. Other types of dementia, such as Alzheimer's disease, have no obvious link to bloodflow, but some experts think that blood pressure may still be somehow contributory in some cases." -BBC News, 2008. Blood pressure 'link to dementia'. BBC News [online], Tuesday 8 July 2008. http://news.bbc.co.uk/2/hi/health/7492959.stm From those studies, we can safely assume that correcting high blood pressure would be effective in reducing the risk of dementia. Dietary restriction Dietary restriction, which may include caloric restriction or intermittent fasting increases BDNF production in the brain and thereby protects neurons against excitotoxic injury. This has a rodent-trial and a preliminary human trial which seems to approve that dietary restriction does stimulates BDNF; thus, may be effective in preventing dementia. QUOTE "Dietary restriction (DR) increases the lifespan of rodents and increases their resistance to several different age-related diseases including cancer and diabetes These findings provide the first evidence that diet can effect expression of a neurotrophic factor, demonstrate that BDNF signaling plays a central role in the neuroprotective effect of DR, and proffer DR as an approach for reducing neuronal damage in neurodegenerative disorders." - Wenzhen Duan, JaeWon Lee, ZhiHong Guo, Mark P. Mattson. Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. Journal of Molecular Neuroscience, Volume 16, Issue 1, pp 1-12 , February 2001. http://www.springerlink.com/content/x8n664k411733634/ QUOTE "Serum BDNF levels were significantly higher in patients on the HD ([1.04 (0.74-2.45) vs 0.86 (0.61-1.14)] p = 0.023)..." - Guimarães LR, Jacka FN, Gama CS, Berk M, Leitão-Azevedo CL, Belmonte de Abreu MG, Lobato MI, Andreazza AC, Ceresér KM, Kapczinski F, Belmonte-de-Abreu P. Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet. Prog Neuropsychopharmacol Biol Psychiatry. 10 Jun 2008. http://www.longecity.org/forum/topic/24624...bdnf-in-humans/ My take on the above quoted studies are that practicing dietary restriction, which includes caloric restriction or intermittent fasting, will reduce risk of neurodegenerative diseases. Cell phone radiation This may be weird, but a 2010 study reveal that cell phone radiation may be inhibiting symptoms of Alzheimer's in rodent trials. QUOTE "The study found that if cell phone exposure began before the genetically engineered mice started showing signs of Alzheimer's, they were less likely to develop symptoms later on in life. No one knows how the radiation protects against Alzheimer's, but the team has some ideas. One is that the microwaves create cellular stress in the brain, and that the stress jump-starts DNA repair mechanisms in the brain." - Ker Than. Cell Phone Use May Fight Alzheimer's, Mouse Study Says. National Geographic Daily News [online]. 6 January 2010. http://news.nationalgeographic.com/news/20...sease-mice.html This is more of a trivial knowledge as to not exaggerate the harms of cellular devices on part of their radiation. However, do note that this is merely an animal trial. Even so, if you want to experiment on this, gladly do so and report them here. Epilepsy drug levetiracetam Consuming the epilepsy drug leveltiracetam was found to reverse mental decline of Alzheimer's, in animal model at least. QUOTE "Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease." - Gladstone Institutes. Epilepsy drug levetiracetam reverses memory loss in animal model of Alzheimer's disease. medicalxpress. http://medicalxpress.com/news/2012-08-epil...ses-memory.html "Until larger human trials have been completed, we caution against any off-label use of levetiracetam," Dr. Mucke said. "But the consistency between our findings and those just obtained by our colleagues at Johns Hopkins is truly remarkable and, in my opinion, merits additional clinical trials." With that said, this is not advisable at the moment, but as aforementioned, if you want to experiment on this, gladly do so and report them here. This post has been edited by reconnaissance: Nov 29 2013, 04:21 AM |
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