Brain aging and midlife tofu consumption.


'' Poor cognitive test performance, enlargement of ventricles and low brain
weight were each significantly and independently associated with higher
midlife tofu consumption. ''


http://www.ncbi.nlm.nih.gov/pubmed/10763906




Association of midlife blood pressure to late-life
cognitive decline and brain morphology.


'' Midlife SBP (systolic blood pressure) is a significant predictor of both decline in
cognitive function and MR volumetric measures of brain atrophy in late life ......
long-term impact of elevated SBP on decline in late-life neurobehavioral functioning
is likely to be mediated through its chronic, negative effect on structural
characteristics of the brain.''

http://www.ncbi.nlm.nih.gov/pubmed/9781518

Does Tofu Cause Dementia?

http://nutritionfacts.org/video/does-tofu-cause-dementia/

Tofu vs. Tempeh

http://nutritionfacts.org/video/tofu-vs-tempeh-2/

Too Much Soy May Neutralize Benefits

http://nutritionfacts.org/video/too-much-s...based-benefits/

All things in moderation, and i'm sticking with tempeh

This post has been edited by cloudnine: Nov 27 2013, 09:01 AM

The above study was based on the Honolulu Asia Aging Study, and
has nothing to do with formaldehyde.

That guy in the Nutritionfacts site does not know what he is talking about.


The full text of the study is here :

http://www.healthmegamall.com/Articles/Bab...nArticle260.pdf



Weston Price Foundation : Soy and the Brain.

'' High amounts of protein tyrosine kinases are found in the hippocampus,
a brain region involved with learning and memory. One of soy’s primary
isoflavones, genistein, has been shown to inhibit tyrosine kinase in the
hippocampus, where it blocked "long-term potentiation," a mechanism
of memory formation. ''

http://www.westonaprice.org/soy-alert/soy-and-the-brain


Once you mess around with the hippocampus, particularly the CA1 and CA3
regions, you're messing with long-term memory recall. The result - the hippocampus
starts shrinking.


CA1/CA3 signalling in the hippocampus is responsible for the conversion
of short to long term memories and are one of the first regions to be hit in
Alzheimer's,




Worse, while the above study implicates Isoflavones, aluminium is another
culprit, something I knew long ago is a causative agent in Alzheimer's.

'' The results of this preliminary investigation suggest that the aluminum concentration
in soy products is increased slightly by cooking, particularly in an aluminum pot, and
strongly (as much as 15-fold) by some methods of tofu production. ''


http://www.vegsource.com/harris/brain_aging.htm






This post has been edited by Tham: Nov 28 2013, 08:00 AM

Restoring Memory, Repairing Damaged Brains With An Artificial Hippocampus.

“No hippocampus,” says Berger, “no long-term memory, but still short-term memory.”
CA3 and CA1 interact to create long-term memory, prior research has shown.

http://neurosciencenews.com/restoring-memo...-dr-berger-usc/




High tryptophan diet reduces amyloid plaques
in the CA1 region of the hippocampus.


http://www.ncbi.nlm.nih.gov/m/pubmed/22702392/



" Why Alzheimer's Patients Behave the Way They Do. "


http://www.theribbon.com/articles/behavior2.asp



The hippocampus, short and long term memories.

http://thebrain.mcgill.ca/flash/i/i_07/i_0...7_cr_tra.html#2

Is this thread created to share peer-reviewed studies related to age-based mental decline?
If so, general or specific into prevention and recovery?

Both. General info, peer-reviewed or anecdotal reports, on any form of dementia
- cognitive decline and senility in old age or from diseases like heart failure and
diabetes, as well as specific into Alzheimer's, vascular dementia and related
degenerative diseases.

What helps to improve cognition and memory (''smart'' drugs and nutrients) will
also generally help Alzheimer's and dementia.

I posted a lot of these studies on the local Alzheimer's Foudation's forum and blog
some years ago, as well as linked them to the thread in the Immortality Institute's
forum, but they deleted them all.

Apparently they are sponsored by the drug firms, so naturally did not take kindly
to outsiders suggesting supplements and herbs.

I understand.

Let's go through the studies and news per category, and now I may research upon preventive measures as for convenience.
By studying the causes or the matters that exacerbates dementia or Alzheimer's, we can draft out a plausible preventive measure, or assumptive solution.

Correcting high blood pressure
High blood pressure is cited by two studies as to exacerbate dementia.

-BBC News, 2008. Blood pressure 'link to dementia'. BBC News [online], Tuesday 8 July 2008.
http://news.bbc.co.uk/2/hi/health/7492959.stm

From those studies, we can safely assume that correcting high blood pressure would be effective in reducing the risk of dementia.

Dietary restriction
Dietary restriction, which may include caloric restriction or intermittent fasting increases BDNF production in the brain and thereby protects neurons against excitotoxic injury.
This has a rodent-trial and a preliminary human trial which seems to approve that dietary restriction does stimulates BDNF; thus, may be effective in preventing dementia.

- Wenzhen Duan, JaeWon Lee, ZhiHong Guo, Mark P. Mattson. Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. Journal of Molecular Neuroscience, Volume 16, Issue 1, pp 1-12 , February 2001.
http://www.springerlink.com/content/x8n664k411733634/

- Guimarães LR, Jacka FN, Gama CS, Berk M, Leitão-Azevedo CL, Belmonte de Abreu MG, Lobato MI, Andreazza AC, Ceresér KM, Kapczinski F, Belmonte-de-Abreu P. Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet. Prog Neuropsychopharmacol Biol Psychiatry. 10 Jun 2008.
http://www.longecity.org/forum/topic/24624...bdnf-in-humans/

My take on the above quoted studies are that practicing dietary restriction, which includes caloric restriction or intermittent fasting, will reduce risk of neurodegenerative diseases.

Cell phone radiation
This may be weird, but a 2010 study reveal that cell phone radiation may be inhibiting symptoms of Alzheimer's in rodent trials.

- Ker Than. Cell Phone Use May Fight Alzheimer's, Mouse Study Says. National Geographic Daily News [online]. 6 January 2010.
http://news.nationalgeographic.com/news/20...sease-mice.html

This is more of a trivial knowledge as to not exaggerate the harms of cellular devices on part of their radiation.
However, do note that this is merely an animal trial.
Even so, if you want to experiment on this, gladly do so and report them here.

Epilepsy drug levetiracetam
Consuming the epilepsy drug leveltiracetam was found to reverse mental decline of Alzheimer's, in animal model at least.

- Gladstone Institutes. Epilepsy drug levetiracetam reverses memory loss in animal model of Alzheimer's disease. medicalxpress.
http://medicalxpress.com/news/2012-08-epil...ses-memory.html

"Until larger human trials have been completed, we caution against any off-label use of levetiracetam," Dr. Mucke said. "But the consistency between our findings and those just obtained by our colleagues at Johns Hopkins is truly remarkable and, in my opinion, merits additional clinical trials."
With that said, this is not advisable at the moment, but as aforementioned, if you want to experiment on this, gladly do so and report them here.

This post has been edited by reconnaissance: Nov 29 2013, 04:21 AM

The racetams are well-known nootropics. Even the first-generation
piracetam will be of some help.

That was what the neurologist gave my father after his stroke a few
years ago, while I told my naive elder brother that he was way behind time,
and that even the far more potent second and third-generation aniracetam or
pramiracetam had already been on the market over a decade ago.

I can easily at least improve my father's dementia with a whole regimen of
smart drugs and supplements anytime, but I am not allowed to even give
him a simple multivit, being blocked by him, and secondly by those
ignorant idiots in the nursing home where he is living.





This post has been edited by Tham: Nov 29 2013, 06:05 AM

Clinical study of Reinhartdt and sea cucumber capsule combined
with donepezil in treating Alzheimer's disease.

http://www.ncbi.nlm.nih.gov/m/pubmed/17342994/



A double blind study on the Reinhardt and sea cucumber
capsule in treating dementia of the aged.

http://en.cnki.com.cn/Article_en/CJFDTOTAL-LYBJ200001004.htm



Clinical study of combined treatment with compound Reinhartdt and
Sea Cucumber Capsule and donepezil for vascular dementia.

http://www.ncbi.nlm.nih.gov/m/pubmed/17990453



The protective effect of eicosapentaenoic acid-enriched phospholipids from sea
cucumber Cucumaria frondosa on oxidative stress in PC12 cells and SAMP8 mice.

http://www.ncbi.nlm.nih.gov/m/pubmed/24231470/




The SAMP8 mouse: a model of Alzheimer disease ?

http://www.ncbi.nlm.nih.gov/pubmed/12014843



From aging to Alzheimer's disease: unveiling "the switch"
with the senescence-accelerated mouse model (SAMP8).

http://www.ncbi.nlm.nih.gov/m/pubmed/19096160/

'' Sea Cucumbers Fast Track Organ Regrowth By Healing Their Wounds. ''

http://www.sciencedaily.com/releases/2007/...71017194617.htm



Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima.

http://link.springer.com/article/10.1186%2F1471-213X-9-3



Regeneration of the enteric nervous system in the
sea cucumber Holothuria glaberrima.

http://www.ncbi.nlm.nih.gov/pubmed/10205023

Its 2020 now and the 2 most promising drugs that is soon to be made available is from USA which is Biogen Aducanumab and China Green Valley Oligomannate

Hopefully will be out soon..

Source: Blood test may accurately predict Alzheimers