Challenge! Draw two! Muahahahaha! Quickdraw McGraw style!

Correction. You CAN play the Wild Draw Fours, but be prepared to be challenged if you do so out of spite. I got challenged when i drew that card, but was not accepted although i got a Wild card on my stack.

Bro, just drop me an invite, im always game for UNO.

Open the game, go Multiplayer, create a new game. Once you are in the lobby, open up your friends list, choose a particular friend on that list, and then choose the option "Invite to game".