i only use WoW ui bar. enough for me. but now it feels like i need a few more extra buttons just because i'm getting more items that i use frequently.

i only use set 1 & 2....and the side & bottom bars. set 1 & 2 are seperated in certain groups
eg. shadow priest; set 1: shadow/damage spells
set 2: healing

mage; set 1: single target spells, plus nova (arguably most important for a mage)
set 2: aoe

correct me if i'm wrong but i think you can target yourself if you hold down the alt button without actually deselecting your target.
might not work with clicking though.

reason i think this works.
when fighting enemies with a priest, i hold down alt & dispell. i will get dispelled. but when i don't hold down alt, i dispell target.