Basically, the Asia region is a server you'd NEVER EVER want to be in. Seriously, 1 hour queue for log-in, jam packed with people.
I've never played in the Asia region but that's what people say when they tried the Asian server.

Just play in the US region, lower latency. Plus, you won't have to deal with all the gold farmers from China. They'll destroy the AH.

The SEA version of the game, by default redirects you to the US region. There's no difference really compared to the US one.

As for the updates, obviously the US region gets them first
But I think all servers will get updates at the same time.

This post has been edited by barbar554: May 19 2012, 07:36 PM

Reasons why I don't choose the Asian server.

It's overcrowded - you can't log-in (1 hour waiting list, madness! And of course, the infamous Error 37)
Hardly anyone speaks English in the Asia region.
Ridiculously high latency - (800 - 1400ms ping, totally unplayable compared to the US region at 150-400ms ping)

What I mean by gold farmers from China are those people who do nothing but bot all day to farm legendary equips and gold in Hell or Inferno mode.
Just look at all the korean MMOs, their markets are all being monopolized.