medical journal reports on PPARs

http://ajpendo.physiology.org/content/288/2/E287.full

Like the role of vitamins in 20th century, PPARs (Peroxisome Proliferators Activated Receptors) will represent the most important biomedical molecules in the 21st century.

PPARγ-mediated insulin sensitization: the importance of fat versus muscle

Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear hormone receptor that functions as a transcriptional regulator in a variety of tissues. PPARγ activation, e.g., through binding of the synthetic glitazones or thiazolidinediones (TZD), results in a marked improvement in type 2 diabetic patients of insulin and glucose parameters resulting from an improvement of whole body insulin sensitivity. The role of different metabolic tissues (fat, skeletal muscle, liver) in mediating PPARγ function in glucose and insulin homeostasis is still unclear. Recently, the function of PPARγ in adipose tissue and skeletal muscle has been intensively characterized by using targeted deletion of PPARγ in those tissues. In those studies, adipose PPARγ has been identified as an essential mediator for the maintainance of whole body insulin sensitivity. Two major mechanisms have been described. 1) Adipose PPARγ protects nonadipose tissue against excessive lipid overload and maintains normal organ function (liver, skeletal muscle); and 2) adipose PPARγ guarantees a balanced and adequate production of secretion from adipose tissue of adipocytokines such as adiponectin and leptin, which are important mediators of insulin action in peripheral tissues. In contrast to studies in adipose-specific PPARγ-deficient mice, the data in muscle-specific PPARγ−/− mice demonstrate that whole body insulin sensitivity is, at least in part, relying on an intact PPARγ system in skeletal muscle. Finally, these early and elegant studies using tissue-specific PPARγ knockout mouse models pinpoint adipose tissue as the major target of TZD-mediated improvement of hyperlipidemia and insulin sensitization.

peroxisome proliferator-activated receptor-γ (PPARγ) belongs to the family of PPARs, which also includes the isoforms PPARα and PPARδ. The PPARγ gene gives rise to at least three mRNAs, PPARγ1, PPARγ2, and PPARγ3, that differ at their 5′ end as a consequence of alternate promoter usage and splicing.

Its great to read this information. This post is very useful to make people aware with regards to this matter. My dad has this condition and I'm glad that you have explained it here clearly. Thanks

http://www.medscape.org/viewarticle/514729
Targeting Insulin Resistance: PPARs, Type 2 Diabetes, and Cardiovascular Risk

Introduction
Insulin resistance (IR) is widely recognized as a core physiologic defect contributing to the development of both type 2 diabetes and cardiovascular disease (CVD).The majority of individuals with type 2 diabetes are known to be insulin-resistant, and this IR, when coupled with an inadequate pancreatic beta-cell response, results in hyperglycemia.[1] Both clinical and epidemiologic data support the association between IR and an increase in CVD risk. IR is associated with the development of a cluster of characteristic CVD risk factors, including hypertension; an atherogenic dyslipidemia (characterized by low high-density lipoprotein cholesterol [HDL-C], increased triglycerides, and an increase in the prevalence of small, dense low-density lipoprotein [LDL] particles); and a proinflammatory, prothrombotic vascular environment, all of which likely contribute to the increase in CVD risk observed.

Given the accepted role of IR in the pathogenesis of diabetes and CVD, therapies that improve insulin action are used commonly for the management of hyperglycemia in diabetes. Moreover, there is significant interest in diabetes therapies that may limit CVD risk. Specifically, the impact of peroxisome proliferator activating receptor (PPAR)-gamma agonists, such as the thiazolidinediones (TZDs) on both diabetes control and CVD risk, has been widely discussed. These PPAR activators are well known to improve glucose control -- in great part by improving insulin action in the periphery -- and may improve a number of CVD risk factors, including hypertension, dyslipidemia, and the vascular, hemodynamic, and hemostatic abnormalities that are common in those with diabetes.

This post has been edited by greenlife: May 4 2012, 09:20 PM

Thanks for more of this info. It really helps.

Diabetes is NO MORE Silent Killer, Crypto PPARS
http://forum.lowyat.net/topic/2261881

this is the impact of peroxisome proliferator activating receptor (PPAR)-gamma agonists, such as the thiazolidinediones (TZDs) on both diabetes control and CVD risk, has been widely discussed...
now can get in this crypto product....

stop your one liner replies...................

Hi Naznaz95, before you check for diabetes or any other illnesses, always check to make sure that your medical card is having sufficient limit.

Because the next thing you'll need (if the tests are positive) would be treatments/medications. Its like going for a routine car maintenance, but without having the standby cash to pay should the 'mechanic' says that the valve is blocked and it needs major overhauling.

Go to any nearest klinik kesihatan. Screening process is Rm1. Subsequent treatment also Rm1. See DR + consultation + medications + blood investigations = Rm1.

change to protein-base food like chicken, meat, fish

take carb during breakfast and lunch as normal (1 plate i mean for normal)

take only small portion carb during dinner

take ur dinner before 8

do not take any junk food/carbonate drink

and dont forget exercise 30min/3 times/weekly

i think i have diabetes la.. i'm going to doctor tonight because i have the symptoms.. like headache after eating carbs or sweet food, urinate frequently and always feels thirsty.. haih i'm not even 18 and i don't usually eat sweet food.. maybe it's genetic

edited

i just went to the doctor and he said i'm fine.. my blood glucose level is 5.6(aftermeal) which is normal..i'm maybe allergic to some artificial sweetener that cause the headache and frequent urinating.. so guys if you really show the symptoms you have to go to doctor to confirm whether you are a diabetic or not.. you really can't determine just from reading the symptoms..

This post has been edited by anggaPra: May 18 2012, 03:05 PM

Diabetes is rising alarmingly in Malaysia, reaching edemic
proportions. Some 18% of the population is diabetic, up
from less than 1% nearly 50 years ago.


http://thestar.com.my/news/story.asp?file=...950&sec=central


" .... in 2008 nearly 17% of the general population of Malaysia had diabetes mellitus. "

http://www.medicalnewstoday.com/releases/118179.php


This was in 2004 :

" In my previous Editorial, prevalence was noted to be only 0.650% in 1960
and in the early 1980s, 2-4%. We has made much ‘progress’ since then:
surveys in the mid-1990s showed a prevalence of about 8-12% while a
recent report of our study undertaken in 1998 showed a prevalence of
diabetes amongst rural and semi—urban populations of 14.0% (range 7.1%
to 20.3%). We are now six ears since our last survey; it may not be
unreasonable to estimate a current prevalence in the range of 16— 18%.
Assuming just 40% of the population (estimated at 25 million) are 30 years
and above, we should have at least 1.6 million adult diabetics in this country now. "

" Worse still, Type 2 diabetes is seen as no longer a disease of middle or old age
— children as young as 10 years old suffering from diabetes (both Type 1 and
Type 2) are not an uncommon sight nowadays. "


http://myais.fsktm.um.edu.my/6088/


In 2007 :

" I have seen children as young as seven coming in with this type of diabetes.
This was rare five years ago. "

http://www.diabetes.org.my/article.php?aid=152



" 54% of the adult population is either obese or overweight,
compared to only 24.1% 10 years ago. As a result 7 out of 10
Malaysian adults suffer from chronic diseases. "

http://www.consumer.org.my/index.php/healt...s-are-diabetics


" The Chinese must be doing something right as there was only a two
per cent increase from 25.6 per cent to 27.6 per cenI. "

http://www.diabetes.org.my/article.php?aid=941



" There is growing evidence that High Fructose Corn Syrup (HFCS),
a cheap substitute for sugar used in processed foods and drinks
may facilitate insulin resistance, and eventually lead to Type 2 diabetes. "

http://www.consumer.org.my/index.php/healt...s-are-diabetics



The situation looks even worse in the Arab countries,
especially the UAE. 35% of kids under 14 there are diabetic.

http://www.redorbit.com/news/health/167962...ates/index.html

NCDs rising at alarming rate.

http://www.nst.com.my/latest/ncds-rising-a...ng-rate-1.83483

Hi Zeliard,

The medical card is not only for the diabetes. The point is that medical insurance especially health card needs to be obtained before any illness creeps in. Diabetes is subjected to a 4 month waiting period. But unless there is specific need to go into details on this, I shall not want to turn this thread into insurance thread.

It is also true about what you've mentioned. People who needs long term medication, it is best to get it from KK.

Apologize for the intrusion.

halo

i age 30 can i buy insuran and how much ya

i got diabetis 170cm 53kg

Once you are confirmed diebetic, no insurer will give you or sell u any medical insurance. There are so many insurance co approached me even when I was in the 20's and after medical checkup and hearing I have diebetic, none of them wanted to give meany medical insurance. Life insurance yes but with loading@&$&@

Since ts no longer active since mid last year, I think I should add another type of diebetic that is less well known I.e type 1.5. Yes it might look like a joke but it's indeed new term since early 90s. Another name is Latent autoimmune diabetes. This mostly on ppl that earlier detected as type 2 but slowly, the oral drugs that they took or even the limited insulin the type 2 can produce slowly getting worse and developing condition like type 1. Read more here

http://en.wikipedia.org/wiki/Latent_autoimmune_diabetes

I am probably this type by now. Well need further confirmation and testing by doc for sure haha

If diabetic, usually offer Life coverage and Accidental Death coverage only, and that also need to pay higher premium than normal people. Critical Illness and Permanent Disability usually declined.

But if overall profile is good, u can appeal for CC or TPD coverage, perhaps can give but with higher premium.

have you try victoza?

this for type 2 diabetis only rite?

Meant for type 2 treatment but clinical trials show that it helps Type 1 too.