Do a 4 channel amp able to power 4" speaker , 6.5" speaker,. Tweeter and woofer. It get very hot when i play song for 15 minutes

connections diagrams and amp spec helps here.

if you asked me that way... i say "can~~~" but its based on the sets of wiring diagram in my head, might not be the same as what you have...

only if u have a 3 way passive crossover for the 6.5"+ 4"+ tweeter using the front 2 channels, and then bridge mono the rear 2 channels for the sub