yea u can. a dremel will do fine. but the outcome maybe not so nice. if u got access to some1 with holesaw that'll be nice. if not bring to those advertisement board company ask them cut for u. most of them got laser cutter for acrylic
another technique which i came up with is a bit extreme but gets the job done pretty well.
get those metal pot cover that measure around 120. u dun need exact. 180-200 will do nicely. heat the area u wan the hole to be with a heatgun then push the cover down.
it'll slice through the acrylic like butter. let it cool and solidify. then pull out the pot cover u'll get a nice hole. but this method if ur pot cover the sides too big it'll push some plastic away so u need to remove them after. but not bad a cheapo technique lol

This post has been edited by valor89: Dec 26 2011, 03:57 AM

well technically u can use a soldering iron. but u'll sooner or later spoil ur soldering iron and i'm not sure the fnish very nice. if u dun mind unexpected results then sure it does work