Four. At least two more to go. I never knew that Tung Shin's Shimadzu
machine was firing at 100 kilovolts, even if for just 2 milliseconds. . That's
quite a shot of gamma rays.
I think I'll go over to Damai Service Hospital next round.
Yes, I know those are blind searches. They were meant to be, largely
to show the countless studies showing the association between tumor
suppressor/oncogenes and cancer, particularly p21, since Tjinn maintained
that there was no link whatsoever between this gene and cancer.
The searches were than progressively narrowed down from "cancer" to "lung cancer"
and finally "SCLC", to show the association between these genes and SCLC. Maybe
I should have searched with them in parathenses, since that would reduce the number
of hits further.
The final two studies and the French p53 site were meant to show the possibility
of low-dose x-rays causing mutations in these genes, particularly p53, thus
predisposing us to cancer, including that of the lung, since Tjinn noted that the "patient's
fate has already been determined from birth".
http://p53.free.fr/Database/p53_cancer/p53_Lung.htmlhttp://www.ncbi.nlm.nih.gov/m/pubmed/8640750/http://www.ncbi.nlm.nih.gov/m/pubmed/18271921I am familiar with p53, p21 and ras - I come from this site and their forum below.
http://www.imminst.orghttp://www.longecity.org/forum/Around half of the posts so far in these two threads are mine.
(I am not in the medical field, not do I even have any degree. I'm
just an ordinarly lowly-paid penpushing layman.)
http://www.longecity.org/forum/topic/25952-cancer-knowledge/http://www.longecity.org/forum/topic/23093...imers-research/I joined Bill's extensively long thread a bit late in his advanced SCLC, though.
http://www.longecity.org/forum/topic/23038...ighting-cancer/SCLC is a very complex cancer with many genetic deletions/mutations (the Immortality
Institute's members are far more familiar with this than me) as the disease progresses,
which is why it relapses so rapidly after an initial good response to chemo.
I am also familiar with some of the other genetic/signalling pathways in cancer -
Bax, Bcl2, caspase 3, PKA, PKC, AKT, PI3K, PPAR gamma, CXCR4, CCR5, etc.
This was the main reason why Bill took high dose resveratrol. Unfortunately, we
didn't realize at that time that resveratrol's bioavailability, at least in humans, is
very poor and disappointing against cancer in vivo (seems to work very well in
dog cancer).
http://www.longecity.org/forum/topic/23038.../page__st__2580http://www.longecity.org/forum/topic/23038...230#entry283230I mentioned the Chinese herbs, Scutellaria baicalensis and barbata, to him right from
the start when I joined his thread, but somehow it didn't really get thru him, I guess
mainly because he was unfamiliar with Chinese cancer-fighting herbs.
I believe that one of the main reasons why cancer patients deteriorate rapidly
when the cancer relapses, with the cancer refractory to second or third-line
chemotherapy regimens, is because the first-line chemo has cleaved their
p53 beyond repair, leaving the patient virtually defenceless. The cancer comes
back and "steamrolls" over them. Our first-line genetic defence against cancer
is, I believe, p53.
Added on April 10, 2012, 4:22 am" For B-cell ALL, even one X-ray was enough to moderately increase the risk. "
http://newscenter.berkeley.edu/2010/10/04/x-ray/http://www.dailymail.co.uk/health/article-...isk-cancer.htmlhttp://articles.mercola.com/sites/articles...y-part-one.aspx X-Rays, Cancer and Heart Disease"
The inability of human cells, to repair correctly every type of radiation-induced
chromosomal damage, has been demonstrated in nuclear workers (who received
their extra low-dose radiation at minimal dose-rates) and in numerous studies of
x-ray-irradiated human cells
at low doses. "
" Besides demonstrating
non-repair or imperfect repair, such studies have established
that x-rays have an extremely low doubling-dose for structural chromosomal mutations. "
"
X-rays are capable of causing virtually every known kind of mutation — from the
very common types to the very complex types, from deletions of single nucleotides, to
chromosomal deletions of every size and position, and chromosomal rearrangements
of every type.
When such mutations are not cell-lethal, they endure and accumulate
with each additional exposure to x-rays or other ionizing radiation. "
\
"
Ionizing radiation is firmly established by epidemiologic evidence as a
proven cause of almost every major type of human cancer. Some of the
strongest evidence comes from the study of medical patients exposed to
x-rays — even at minimal dose-levels per exposure. "
http://www.drheise.com/xrays.htmJohn Gofman's book -
Radiation from Medical Procedures in the Pathogenesis of
Cancer and Ischemic Heart Disease :
Dose-Response Studies with Physicians per 100,000 Populationhttp://www.ratical.org/radiation/CNR/RMP/index.htmlhttp://www.ratical.org/radiation/CNR/RMP/chp1F.htmlyour meant to be blind searches showed alot of irrelavent information. it would be better if u could link it to a proper article or research paper so we can have a better discussion going on.
alright. currently there is no established proof that p21 supression predisposes to carcinoma.
studies have been done before with p21 knock out mice. most of them have not yielded satisfactory responses.
and as for p53 i maintain what i said.
it is rare and most commonly seen as Li-fraumeni syndrome which is an autosomal dominant disorder.
in which it will be inherited to the off spring regardless. thus his fate has been determined since birth.
i also did mention that it can be acquired. more so commonly by long term hpv infection. for xrays it takes many years. 15 - 20 years
of constant exposure.
i'm very interested to see what are behind those links. but please forgive my short reply. i'll go through it after work.