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Given the Blues' slump of late, they would be the least favourite to reach the final at Wembley out of the four English sides which includes the likes of Manchester United, Arsenal and Tottenham.
Carlo Ancelotti's men are currently languishing fifth in the Barclays Premier League and their place in next season's Champions League is in jeopardy.
But Lineker has backed the reigning English champions to put their domestic woes behind them and achieve the European glory they have been craving for.
"Chelsea have struggled this season but they've got so many good players they can turn it round," he said. "I expect them to be London's best bet for a finalist.
"It's a massive draw for all the clubs involved. It will be extra special to play in a Champions League final on home soil.
"It's at Wembley, a London final, it would be quite something to have a London club in it. Obviously there are four clubs still in it. The first two who played this week have given themselves a good chance.
"Manchester United will make it to the quarter-finals and I believe there will be at least three English clubs in the next round."
Speaking on his former side Spurs, the BBC frontman, like everyone else, has been impressed with Harry Redknapp's men this season but is not too sure if they have what it takes to make it to the final on 28 May.
He said: "It's Tottenham's first season in the competition, it's a huge ask for them them to go all the way, it will be one hell of an achievement.
"It's great experience for Spurs, it's brilliant they've come this far. I would think they'd be very happy with getting to the quarter-finals.
"But this tournament has thrown up the odd surprise. Look at last year, no one was backing Inter Milan to go all the way. You never know."
Meanwhile, Spurs' local rivals Arsenal have been equally as impressive, beating Barcelona 2-1 in the first leg of their last 16 Champions League tie at the Emirates last Wednesday.
And the 50-year-old is adamant the Gunners have what it takes to do finish the job in the second-leg at the Nou Camp.
The former England international added: "Arsenal are gradually improving, you can see they are better than they were last year. You look at them and you can see there are certain weaknesses, in the centre of defence which might be exploited out in the Camp Nou.
"But their players are maturing and there are more young players coming through. And they play wonderful football, similar to Barcelona's.
"They're not as good in some positions as Barca but they're always easy on the eye, they're always great to watch."
Lineker made 105 appearances for Spurs and scored 67 times during three years at White Hart Lane

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Feb 21 2011, 04:41 PM, updated 15y ago
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