HT 20 kills is easy, cannon rush early on, kill all building except nexus, then rush HT.

everything else works with AI. league is strictly league. however, i had mule x'ing worked on AI (but i was playing 2vs2 insane AI coop with friend) so i guess some of them work (unintentionally) while the rest doesn't. for example, a roach life, defo doesnt work. i had that on a league game, where we already won the 3v3, and left the 1 guy, 3vs1, so i just bring a roach, goto his photon cannon, keep taking hits, regen, rinse repeat till achieve LOL.