be aware some of the features you turn off might cause problems.

Last access time stamps - not much problem if disable this just that you won't be able to find out files updated when. Some people do use this but most people doesn't. Quite safe to turn this off.

The Master File Table - quite save to play around with this but will also create problem if you MFT is corrupted. You won't be able to access your whole HDD. Safer if you use Diskeeper. This program will defrag MFT for you and will also let you resize MFT easily.

Short filenames - if you run some old programs that still uses 8.3 naming system then that program might not run. But overall windows core system should have no problem running.