QUOTE(Mesosmagnet @ Jan 12 2010, 04:13 PM)

I came across this picture many times while doing some reading. This picture states the facts that a recessive deleterious allele will become dominant in offspring born of 2 carriers of the deleterious allele. But it seems to have removed the other possible outcomes.
Aa + AA = { AA, Aa, Aa } the assumption is that the deleterious allele is more likely to be passed on rather than the dominant beneficial allele? According to probability shouldn't the chances of offspring with AA and Aa be equal?
Aa + Aa = { aa } and where have the other possible outcomes gone? Aa + Aa = { AA, Aa }. Yet again in terms of probability the chances of producing offspring with Aa should be higher than aa and AA.
Now lets define a new diagram: (only inbreeding, no crossbreeding)
First Stage :
AA + Aa = { AA, AA, Aa, Aa }
Second stage :
AA + AA = { AA, AA, AA,AA }
Aa + Aa = { AA, Aa, Aa, aa }
Third stage :
AA + aa = { AA, Aa, Aa, aa } but if natural selection were to be present aa wouldn't get a chance to reproduce no? **
Aa + aa = { Aa, aa, aa, Aa }
**Over time, natural selection weeds deleterious alleles out of a population — when the dominant deleterious alleles are expressed, they lower the carrier's fitness, and fewer copies wind up in the next generation
Already by the 3rd generation we see that the AA individuals are more abundant than individuals with Aa and aa.
I am assuming that we can compute the outcome of genetic drift using probability.
Another point to ponder : what if there were a recessive beneficial allele? What outcome would we get then?
A being the dominant allele will suppress the recessive a. so Aa while carrying bad genes, the bad quality is not express and the individual live a healthy life.
so as far as quality of life is concern, Aa and AA has no difference. while aa is catastrophic. in case of a large population, the chance of aa being expressed is significantly lower than AA or Aa as opposed to a small sample size of inbreeding.
as shown in the your example, by the third generation, 3/8 has aa. (1/8 at 2nd)
comparatively in crossbreeding, the chance of aa being expressed is significantly lowered.
not not neccessary all a is bad, there is a possibility that ou have some recessive genes that are good. but life prefer to err on the side of safety. its basic instinct. you prefer to take a risk if its to protect something you already have rather than to take a risk to get something that may benefit you.
Added on January 13, 2010, 12:51 amQUOTE(Dickson Poon @ Jan 12 2010, 05:46 PM)
What is the basis of your assertion that male preferences have shifted from plump women to slim women?
Also if the time period of human history up to the present and five hundred years in the future is too short to produce any meaningful results in human evolution, then what's all the fuss about humans not evolving anyway? The time scale we are talking about would still be too short despite the technological advances and changes in human lifestyle.]
see difference from renaissance to present dayalso
some articlenow, i am not saying plump women are unattractive or vice versa, but society in general views slimness (hour glass) as the ideal female figure now, versus the plumpier version as the ideal 500 years ago.
there are numerous psychological and economical reasoning into why this happened, if you are interested in learning more.
yes, current age with medicine and technology is too short to produce any significance in evolution pressure, but if the current trend continues, we will see human as a species rely more and more on technology and medicine, and less on any evolution that occur (ie, the one that is more susceptible to illness get more or less the same chance to reproduce as the healthy one)
Added on January 13, 2010, 1:04 amQUOTE(thesupertramp @ Jan 12 2010, 11:00 PM)
I still disagree. Humans have used medicine to treat themselves for thousands of years, possibly millions. Other animals have shown similar traits as well (dogs eating grass). Now, although Lamarckism is distinct from Natural Selection, it does play a significant role in a species's survival.
It is true that genetically our genes might not be "better" due to medicine, but the use of modern medicine can be equated to similar traits demonstrated by other primates, such as calling out when they see danger so that their entire group can flee. Thus, both forms can be said to provide evolutionary advantage to a species, but Darwin's evidence seem to suggest team work is more important. In
The Descent of Man, he noted that tribes that demonstrated better team work usually triumph over those that do not.
naturally occuring medicine dont usually have as wide and deep effect as artificial medicine. and knowledge of medicine is not genetically passed on (at least not for human)
lamarckism does not play any role in species survival, because it does not happen. it is not an "alternative" path of evolution, it is a mistaken path of evolution.
you have thick pads on your fingers and feet because your body has the ability to develop harder skins at places where more stress is applied. your fingers are more flexible because you practise it more and your muscle and tendons did not harden. these are naturally occuring adaptation that you as an individual can perform. at no time is this information passed on to your offsprings. a baby is always born is soft smooth soles even though their parents are hard laborers with calloused feet and hands.
AND, grass is not "medicine" to dogs, at least not in the sense you are implying.
dog eat grassThis post has been edited by lin00b: Jan 13 2010, 01:11 AM