No matter how advance the theory, human physical build is not meant for that aka our body is not suit for other environemental outside of earth condition.

It is already known that bone become porous if living too long in the space, that's why we see astraunaut need to regular work their muscle/exercise if staying too long in the space/ISS.

Human body will have difficult to adjust the different gravitational problem as well.

To adapt the difference, any living organism takes long considerable time to adapt, which is not something a few generation gap that can do it one.

Besides, we have lot of sustainability issue living outside of earth. There are lot of condition that we are taking for granted without noticing the importance of them. Even in earth, human cannot live on our own, we need plants, animals, insects, wind, wave, etc, which completed the self sustainable cycle.