People on here seem fairly good at finding medical studies--discussions of reliability/bias notwithstanding--so here's a (very specific) challenge: Can anyone find material that addresses how blood thinners like Coumadin/warfarin may affect strength training?

My haematologist was ambivalent when I last saw him, and my own quick search came up with a bunch of idiots talking about how NO-Xplode is banned in Australia because "it contains rat poison (warfarin)," but nothing useful beyond that. I'm particularly interested in what might be happening at the micro level (muscle tears, etc.).

Thanks in advance, fellas.

Note:
I'm already very, very, very familiar with what warfarin is and what its general effects are. I'm interested in learning specifically about its use in relation to my workouts.

This post has been edited by angrydog: Sep 3 2009, 11:54 AM

Now u see nobody will reply wan.

I'm disappointed I should've asked to be linked to a study about how drinking cold water gives you stomach cancer or heart attacks.

I don't know much about Hematology but I know that Warfarin is some kind of oral drug that helps reduce the risk of stroke (anticoagulant). The downside of it is it interferes with the action of Vitamin K (works as a posttrans mod of certain proteins) in production of some procoagulants. ( something to do with an impaired liver function ). So I'm assuming that if you consume Warfarin, since it interferes with Vitamin K, you might have some side effects in terms of protein synthesis. maybe....

Thats all I know, and there are definite chances that I am talking bull-crap.

I think only darklight is able to enlighten you on these kind of stuffs since he has a med. background.

An approximate 1:30 ratio of reply and views...A good example of how much people around here try to sound real smart but in the end they know nothing...hahahahha...

This post has been edited by shanecross: Sep 3 2009, 11:12 AM

If I claimed that Coumadin had a steroid-like effect, the ratio would be more like 1:10000000

Warfarin inhibits blood coagulation, making you bleed easier, with weight training, heart rate increases and stroke volume increases causing high blood pressure and with stretching of the muscles during weight lifting can easily rupture small blood capillaries and the clotting factors II, VII, IX and X, protein C, protein S, and protein Z synthesis is inhibited by warfarin so clotting of the ruptured blood vessel cannot take place, causing hematomas (blue blacks) or hemorrhage.

So if you're squatting, blood vessels in the knee might get ruptured and coagulation fails and you'll bleed into your knee joint.

http://en.wikipedia.org/wiki/Warfarin

I can't find any journals about warfarin use during exercise, but there are studies about warfarin use in elderly people with myocardial infarction during exercise to reduce platelet aggregability, mainly to prevent further thromboembolitic attacks.

http://www.sciencedirect.com/science?_ob=A...0ac1ec53cf8cbea

Go to scholar.google.com to find more journals about it.

This post has been edited by Florian: Sep 3 2009, 11:39 AM

I'll rep you if i could.

i use NO-Xplode
Didn't notice the warfin effect

I just get more energy and endurance during traiining