QUOTE(Jedi @ Dec 23 2009, 04:33 PM)
I have a clinical question on Physiology
Doctor administers barbiturate during anesthesic before operation, the patients stops breathing. Doctor gives artificial source of oxygen but patients die in the end....Why is that so?
Pls help ASAP! thank u!
"IMO, barbiturate is inhibiting respiratory control in Medulla oblongata - therefore even though u have oxygen, Carbon dioxide cannot be exhaled out, person dies of acidosis of alveoli..."
That's probably the reason. Barbs inhibit one's central respiratory centre hence one cannot breathe. Worth pointing out that there's no acidosis of the alveoli - acidosis occurs throughout the body, not just the alveoli; although hypoxia will probably kill the patient first.
Now it's unclear what "artificial source of oxygen" means as there are many ways of administering O2, but for patients who can't breathe you have to intubate and ventilate them mechanically.
I assume this is a hypothetical question for pre-clinical year studies since barbs are rarely used in anaesthetics anymore (benzodiazepines, propofol, and ether gases more commonly used now). Furthermore, the patient wouldn't have died on the table had the 'artificial source of O2' was via intubation with assisted ventilation.
QUOTE(DireAnguish5678 @ Jan 2 2010, 09:45 AM)
Could it maybe have something to do with cerebellar ataxia, maybe scalenes movement are impaired?
Never say never in medicine, as theoretically barbs can cause paralysis of muscles. But as mentioned above barbs are seldom used now. Non-depolarising antiACh agents (pan/vercuroniums) are preferred for muscle relaxation during GA.
The more you are exposed to clinical medicine, the more you realise stuff that you learn in pre-clinical years are for academic interest. Most of the agents you study in pharmacology are no longer first choice in real-life, but the basics must still be taught and learned.
QUOTE(onelove89 @ Jan 3 2010, 09:32 PM)
yeah, depending on the requirement of the university. Some don't require biology as a prerequisite subject to enter medicine, some do. But then again, you'll need to know the fundamentals of biology(I'll say....till form 5/pre-U standard) , if not you'll suffer when you enter the course. Pardon my curiosity, but why medicine when you didn't intend to take biology initially?
Because biology is not a requisite?

I didn't take biology either during SAM, instead I opted for Specialist Maths. That way I could still choose between engineering or medicine, while had I chosen biology without spec maths I wouldn't have such options.
This post has been edited by StarGhazzer: Jan 4 2010, 07:26 AM