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Biology Regrowing Limbs, Ppl who lost their limbs, can rejoice?

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TSWinston LYN
post Jul 11 2009, 12:49 PM, updated 17y ago

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QUOTE
Key Concepts
The gold standard for limb regeneration is the salamander, which can grow perfect replacements for lost body parts throughout its lifetime. Understanding how can provide a road map for human limb regeneration.
The early responses of tissues at an amputation site are not that different in salamanders and in humans, but eventually human tissues form a scar, whereas the salamander’s reactivate an embryonic development program to build a new limb.
Learning to control the human wound environment to trigger salamanderlike healing could make it possible to regenerate large body parts.

Okay guys, here is the link Source.

I've read about this article long ago from MSN websites... US government is now putting their budgets to research on this promising project. Not only using Salamander's theory, also using Stem Cell theory. My question is...will this be feasible in our time to come? Since human genome project is 90% complete. In other words, once we've understood every human genes we can also regrow back lost parts and or smaller important human organs.

No need to wait for donors...user posted image

This post has been edited by Winston LYN: Jul 11 2009, 01:00 PM
weichi
post Jul 11 2009, 02:26 PM

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Sure, give it a decade. I'm sure smth will pop up, maybe for less complex limbs.
TSWinston LYN
post Jul 11 2009, 03:49 PM

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By that time, prosthetic limbs are useless. We just need to regrow lost parts and we can live a much more healthier life.
pleasuresaurus
post Jul 11 2009, 04:57 PM

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I did a short industrial training bout 4 years back at a biotech consulting firm, one of their clients were growing organs. Very interesting really. Their pioneer product at the time were urinary bladders, simple enough structures to grow. They basically get a biopsy of the clients tissue sample, culture the cells and grow the organ on a scaffold immersed with nutrients and growth stims. Since its the clients own tissue, its practically an isograft - no host rejection of the organ. Nifty as f***.
new in IT
post Jul 11 2009, 06:32 PM

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What is other organs in the body like the kidney.
There are so many people have kidney problems.
If the tech allow scientist to 'grow' kidney with the patient's tissue sample, the patient no need to undergo painful blood filter process.

However, will it cause another social problem as people will think that maintaining their health of their body is not necessary as we can exchange a new one!

TSWinston LYN
post Jul 12 2009, 11:25 PM

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QUOTE(new in IT @ Jul 11 2009, 06:32 PM)
What is other organs in the body like the kidney.
There are so many people have kidney problems.
If the tech allow scientist to 'grow' kidney with the patient's tissue sample, the patient no need to undergo painful blood filter process.

However, will it cause another social problem as people will think that maintaining their health of their body is not necessary as we can exchange a new one!
*
Not necessary... because this is a painstaking process that may take long time to grow another organ out. As ppl who have studied Bio before would have known the process : Cell > Tissue > Organ.

So we would need to grow a lot of cells then in turn grow different tissues to form an organ. So health care is still nonetheless still very important to us. We should be afraid of ppl misusing this idea into something terrible...I fear most.
rainpocky
post Jul 13 2009, 12:52 AM

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Wasnt there groups trying to do cloning on human organs to help out mankind. But it became a controversial debate of trying to do human cloning as well and became outlawed in certain countries, like... they cloned a sheep dolly, but that didnt last very long... Maybe today they are trying to do some sort of organ cloning. Would help better than prosthetic or so.
pleasuresaurus
post Jul 14 2009, 08:29 PM

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Simple cell lines are easy to culture, but organs are a mess of many different cells to begin with...its gonna be some time before they even come anywhere close to cloning something as complex as the kidney
TSWinston LYN
post Jul 19 2009, 11:27 PM

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Yup, so far now scientist are only able to clone another life by only using the simplest method. Like the sheep dolly method. However, if cloning parts of human organ is by far still need a lot research to be done in order to fully perfect this science. Oh wow where u did ur industrial training? So cool dude, I wish those ppl who lost their limbs can finally have their lost parts again.


0606088
post Jul 20 2009, 12:13 AM

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if so happen i might wOrry wat would happen to this world.
rainpocky
post Jul 22 2009, 03:47 PM

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Thats just freaky having cloned parts in your body, if you let the scientist clone parts for your body, sooner or later your going to see your own clone walking around.

Cloning your parts... is just like the movie "THE ISLAND", and thats just wrong or murder or genocide. Its gonna lead to something messed up later.
chingwooi
post Jul 25 2009, 04:12 PM

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QUOTE(rainpocky @ Jul 22 2009, 03:47 PM)
Thats just freaky having cloned parts in your body, if you let the scientist clone parts for your body, sooner or later your going to see your own clone walking around.

Cloning your parts... is just like the movie "THE ISLAND", and thats just wrong or murder or genocide. Its gonna lead to something messed up later.
*
Human cloning is forbidden long time ago. However, the stem cell research is good. although this is a little bit out topic but now they're injecting stem cell into myocardial infarction patient and so far the results are pretty promising smile.gif
DoubleU
post Jul 28 2009, 11:35 PM

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Well, for stems cells to 'grow' into an organ, eg. kidney you need to send the correct signals to stems cells, which are undifferentiated, which can be obtain from the umbilical cord. So far its the part of sending the signal to the cells which is the main problem.

Cloning somebody like you, eg. use the same cloning method as dolly. Will most probably not yield any result if your condition is genetic. Because the same failures will most probably occur in the clone.


Now to the topic of cloning limbs and the reason i think the reason that we cannot 'regrow' our limbs is because out skin is one of the few specialized stem cells that can keep dividing. So since our bone, muscle cells cannot do this, the skin just multiplies and covers the wound, thus scarring. Its interesting to note that the salamander still has stem cells in adulthood and since we can't store stem cells so maybe we shouldn't think of 'regrowing' limbs....

*Interesting thought: why did I write this? it has nothing to do with replacing a kidney damaged by diseases due to diabetics.....*

But if its like an organ like the heart and you need to replace it, then you probably can't use it.
Mudmaniac
post Jul 29 2009, 11:28 PM

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The tech is not that far away.

Incidentally, if you even end up in certain sports hospitals in KL, they will ask you whether you want to include "stem cell treatment" with your ACL knee surgery. I really wonder WHOSE stem cells they claim to be using.


 

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